Regulation of insulin-receptor mRNA levels by glucocorticoids.

A. R. McDonald; B. A. Maddux; Y. Okabayashi; K. Y. Wong; D. M. Hawley; C. D. Logsdon; I. D. Goldfine

doi:10.2337/diab.36.6.779

Regulation of insulin-receptor mRNA levels by glucocorticoids.

A. R. McDonald, B. A. Maddux, Y. Okabayashi, K. Y. Wong, D. M. Hawley, C. D. Logsdon, I. D. Goldfine

Cancer Biology

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33 Scopus citations

Abstract

We found with IM-9 human cultured lymphocytes, that the glucocorticoid dexamethasone increased insulin-receptor mRNA levels. This increase correlated in a time- and dose-dependent manner with the increase in the biosynthesis of the insulin-receptor precursor. In addition, in AR42J cultured rat pancreatic acinar cells, dexamethasone increased insulin-receptor mRNA levels. These studies suggest, therefore, that an increase in mRNA levels is an early step in the regulation of the insulin receptor by glucocorticoids in several cell types.

Original language	English (US)
Pages (from-to)	779-781
Number of pages	3
Journal	Diabetes
Volume	36
Issue number	6
DOIs	https://doi.org/10.2337/diab.36.6.779
State	Published - Jun 1987

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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author = "McDonald, {A. R.} and Maddux, {B. A.} and Y. Okabayashi and Wong, {K. Y.} and Hawley, {D. M.} and Logsdon, {C. D.} and Goldfine, {I. D.}",

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AU - McDonald, A. R.

AU - Maddux, B. A.

AU - Okabayashi, Y.

AU - Wong, K. Y.

AU - Hawley, D. M.

AU - Logsdon, C. D.

AU - Goldfine, I. D.

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AB - We found with IM-9 human cultured lymphocytes, that the glucocorticoid dexamethasone increased insulin-receptor mRNA levels. This increase correlated in a time- and dose-dependent manner with the increase in the biosynthesis of the insulin-receptor precursor. In addition, in AR42J cultured rat pancreatic acinar cells, dexamethasone increased insulin-receptor mRNA levels. These studies suggest, therefore, that an increase in mRNA levels is an early step in the regulation of the insulin receptor by glucocorticoids in several cell types.

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Regulation of insulin-receptor mRNA levels by glucocorticoids.

Abstract

ASJC Scopus subject areas

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