Regulation of microRNA-145 by growth arrest and differentiation

Gaspare La Rocca; Bin Shi; Alessandra Audia; Giovanna Ferrari-Amorotti; Hestia S. Mellert; Bruno Calabretta; Steven B. McMahon; Laura Sepp-Lorenzino; Renato Baserga

doi:10.1016/j.yexcr.2010.11.010

Regulation of microRNA-145 by growth arrest and differentiation

Gaspare La Rocca, Bin Shi, Alessandra Audia, Giovanna Ferrari-Amorotti, Hestia S. Mellert, Bruno Calabretta, Steven B. McMahon, Laura Sepp-Lorenzino, Renato Baserga

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest. In order to clarify the functional effects of miR145, we have investigated its expression in diverse conditions and different cell lines. Our results show that miR145 levels definitely increase in differentiating cells and also in growth-arrested cells, even in the absence of differentiation. Increased expression during differentiation sometimes occurs as a late event, suggesting that miR145 could be required either early or late during the differentiation process.

Original language	English (US)
Pages (from-to)	488-495
Number of pages	8
Journal	Experimental Cell Research
Volume	317
Issue number	4
DOIs	https://doi.org/10.1016/j.yexcr.2010.11.010
State	Published - Feb 15 2011

Keywords

Differentiation
Growth arrest
MicroRNAs
Mir145

ASJC Scopus subject areas

Cell Biology

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10.1016/j.yexcr.2010.11.010

Cite this

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title = "Regulation of microRNA-145 by growth arrest and differentiation",

abstract = "MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest. In order to clarify the functional effects of miR145, we have investigated its expression in diverse conditions and different cell lines. Our results show that miR145 levels definitely increase in differentiating cells and also in growth-arrested cells, even in the absence of differentiation. Increased expression during differentiation sometimes occurs as a late event, suggesting that miR145 could be required either early or late during the differentiation process.",

keywords = "Differentiation, Growth arrest, MicroRNAs, Mir145",

author = "{La Rocca}, Gaspare and Bin Shi and Alessandra Audia and Giovanna Ferrari-Amorotti and Mellert, {Hestia S.} and Bruno Calabretta and McMahon, {Steven B.} and Laura Sepp-Lorenzino and Renato Baserga",

note = "Funding Information: This work was supported by grant CA89640 from the National Cancer Institute, NIH .",

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doi = "10.1016/j.yexcr.2010.11.010",

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pages = "488--495",

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TY - JOUR

T1 - Regulation of microRNA-145 by growth arrest and differentiation

AU - La Rocca, Gaspare

AU - Shi, Bin

AU - Audia, Alessandra

AU - Ferrari-Amorotti, Giovanna

AU - Mellert, Hestia S.

AU - Calabretta, Bruno

AU - McMahon, Steven B.

AU - Sepp-Lorenzino, Laura

AU - Baserga, Renato

N1 - Funding Information: This work was supported by grant CA89640 from the National Cancer Institute, NIH .

PY - 2011/2/15

Y1 - 2011/2/15

N2 - MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest. In order to clarify the functional effects of miR145, we have investigated its expression in diverse conditions and different cell lines. Our results show that miR145 levels definitely increase in differentiating cells and also in growth-arrested cells, even in the absence of differentiation. Increased expression during differentiation sometimes occurs as a late event, suggesting that miR145 could be required either early or late during the differentiation process.

AB - MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest. In order to clarify the functional effects of miR145, we have investigated its expression in diverse conditions and different cell lines. Our results show that miR145 levels definitely increase in differentiating cells and also in growth-arrested cells, even in the absence of differentiation. Increased expression during differentiation sometimes occurs as a late event, suggesting that miR145 could be required either early or late during the differentiation process.

KW - Differentiation

KW - Growth arrest

KW - MicroRNAs

KW - Mir145

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Regulation of microRNA-145 by growth arrest and differentiation

Abstract

Keywords

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