Abstract
Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of immunological disorders. NF-κB is a well-known proinflammatory mediator, and its deregulated activation is associated with the chronic inflammation of autoimmune diseases. Paradoxically, NF-κB plays a crucial role in the establishment of immune tolerance, including both central tolerance and the peripheral function of regulatory T (Treg) cells. Thus, defective or deregulated activation of NF-κB may contribute to autoimmunity and inflammation, highlighting the importance of tightly controlled NF-κB signaling. This review focuses on recent progress regarding NF-κB regulation and its association with autoimmunity.
Original language | English (US) |
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Pages (from-to) | 282-289 |
Number of pages | 8 |
Journal | Trends in Immunology |
Volume | 34 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2013 |
Keywords
- Autoimmunity
- Inflammation
- NF-κB
- Regulatory T cells
- Ubiquitination
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology