Rehabilitation Implications of Cellular Therapy for Cancer

Purpose of Review: This paper aims to explore the rehabilitation implications of hematopoietic stem cell transplants (HSCT) and chimeric antigen receptor (CAR) T-cell therapy, addressing the dearth of literature on rehabilitation for CAR T-cell recipients compared to HSCT patients. Recent Findings: While HSCT recipients commonly face weakness and deconditioning, CAR T-cell therapy recipients experience unique toxicities like cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Prehabilitation, rehabilitation, and prospective surveillance have emerged as crucial components in managing these challenges, with multidisciplinary approaches showing promise. Summary: Interdisciplinary prehabilitation and rehabilitation are vital, initiated early and maintained throughout, to effectively address treatment-related sequelae. This review guides future research towards developing targeted interventions and improving outcomes in cellular therapy recipients.