TY - JOUR
T1 - Relations between residential proximity to EPA-designated toxic release sites and diffuse large b-cell lymphoma incidence
AU - Bulka, Catherine
AU - Nastoupil, Loretta J.
AU - Koff, Jean L.
AU - Bernal-Mizrachi, Leon
AU - Ward, Kevin C.
AU - Williams, Jessica N.
AU - Bayakly, A. Rana
AU - Switchenko, Jeffrey M.
AU - Waller, Lance A.
AU - Flowers, Christopher R.
N1 - Publisher Copyright:
© 2016 by The Southern Medical Association.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Objectives Examining the spatial patterns of diffuse large B-cell lymphoma (DLBCL) incidence and residential proximity to toxic release locations may provide insight regarding environmental and sociodemographic risk factors. Methods We linked and geocoded cancer incidence data for the period 1999-2008 from the Georgia Comprehensive Cancer Registry with population data from the US Census and the Environmental Protection Agency's Toxics Release Inventory. We conducted cluster analyses and constructed Poisson regression models to assess DLBCL incidence as a function of mean distance to the toxic release sites. Results In total, 3851 incident DLBCL cases occurred among adults residing in Georgia between 1999 and 2008. Significant focal clustering was observed around 57% of ethylene oxide sites, 5% of benzene sites, 9% of tetrachloroethylene sites, 7% of styrene sites, 10% of formaldehyde sites, 5% of trichloroethylene sites, and 10% of all release sites. Mean distance to sites was significantly associated with DLBCL risk for all chemicals. Conclusions Proximity to Toxics Release Inventory sites can be linked to increased DLBCL risk as assessed through focal clustering and Poisson regression, and confirmatory studies using geospatial mapping can aid in further specifying risk factors for DLBCL.
AB - Objectives Examining the spatial patterns of diffuse large B-cell lymphoma (DLBCL) incidence and residential proximity to toxic release locations may provide insight regarding environmental and sociodemographic risk factors. Methods We linked and geocoded cancer incidence data for the period 1999-2008 from the Georgia Comprehensive Cancer Registry with population data from the US Census and the Environmental Protection Agency's Toxics Release Inventory. We conducted cluster analyses and constructed Poisson regression models to assess DLBCL incidence as a function of mean distance to the toxic release sites. Results In total, 3851 incident DLBCL cases occurred among adults residing in Georgia between 1999 and 2008. Significant focal clustering was observed around 57% of ethylene oxide sites, 5% of benzene sites, 9% of tetrachloroethylene sites, 7% of styrene sites, 10% of formaldehyde sites, 5% of trichloroethylene sites, and 10% of all release sites. Mean distance to sites was significantly associated with DLBCL risk for all chemicals. Conclusions Proximity to Toxics Release Inventory sites can be linked to increased DLBCL risk as assessed through focal clustering and Poisson regression, and confirmatory studies using geospatial mapping can aid in further specifying risk factors for DLBCL.
KW - diffuse large B-cell lymphoma
KW - epidemiology
KW - lymphoma
KW - non-Hodgkin lymphoma
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U2 - 10.14423/SMJ.0000000000000545
DO - 10.14423/SMJ.0000000000000545
M3 - Article
C2 - 27706495
AN - SCOPUS:84989964776
SN - 0038-4348
VL - 109
SP - 606
EP - 614
JO - Southern Medical Journal
JF - Southern Medical Journal
IS - 10
ER -