Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma

Michael R Green; Maher K Gandhi; Mark J Courtney; Paula Marlton; Lyn Griffiths

doi:10.1016/j.leukres.2009.05.004

Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma

Michael R Green, Maher K Gandhi, Mark J Courtney, Paula Marlton, Lyn Griffiths

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkappaB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFkappaB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkappaB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkappaB activity in FL, and could potentially be used as a marker for this gene signature.

Original language	English (US)
Pages (from-to)	1699-702
Number of pages	4
Journal	Leukemia Research
Volume	33
Issue number	12
DOIs	https://doi.org/10.1016/j.leukres.2009.05.004
State	Published - Dec 2009
Externally published	Yes

Keywords

Forkhead Transcription Factors/genetics
Humans
Lymphoma, Follicular/genetics
NF-kappa B/metabolism
Protein Isoforms/genetics
RNA, Messenger/genetics
Repressor Proteins/genetics

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10.1016/j.leukres.2009.05.004

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title = "Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma",

abstract = "FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkappaB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFkappaB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkappaB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkappaB activity in FL, and could potentially be used as a marker for this gene signature.",

keywords = "Forkhead Transcription Factors/genetics, Humans, Lymphoma, Follicular/genetics, NF-kappa B/metabolism, Protein Isoforms/genetics, RNA, Messenger/genetics, Repressor Proteins/genetics",

author = "Green, {Michael R} and Gandhi, {Maher K} and Courtney, {Mark J} and Paula Marlton and Lyn Griffiths",

year = "2009",

month = dec,

doi = "10.1016/j.leukres.2009.05.004",

language = "English (US)",

volume = "33",

pages = "1699--702",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma

AU - Green, Michael R

AU - Gandhi, Maher K

AU - Courtney, Mark J

AU - Marlton, Paula

AU - Griffiths, Lyn

PY - 2009/12

Y1 - 2009/12

N2 - FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkappaB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFkappaB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkappaB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkappaB activity in FL, and could potentially be used as a marker for this gene signature.

AB - FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkappaB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFkappaB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkappaB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkappaB activity in FL, and could potentially be used as a marker for this gene signature.

KW - Forkhead Transcription Factors/genetics

KW - Humans

KW - Lymphoma, Follicular/genetics

KW - NF-kappa B/metabolism

KW - Protein Isoforms/genetics

KW - RNA, Messenger/genetics

KW - Repressor Proteins/genetics

U2 - 10.1016/j.leukres.2009.05.004

DO - 10.1016/j.leukres.2009.05.004

M3 - Article

C2 - 19487025

SN - 0145-2126

VL - 33

SP - 1699

EP - 1702

JO - Leukemia Research

JF - Leukemia Research

IS - 12

ER -

Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma

Abstract

Keywords

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