@article{00b6e4b7d8304a1f880fd20c325980f9,
title = "Relative abundance of sars-cov-2 entry genes in the enterocytes of the lower gastrointestinal tract",
abstract = "There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection.",
keywords = "COVID-19, Gastrointestinal tract, SARS-CoV-2, ScRNA-seq",
author = "Lee, {Jaewon J.} and Scott Kopetz and Eduardo Vilar and Shen, {John Paul} and Ken Chen and Anirban Maitra",
note = "Funding Information: This work was supported by the MD Anderson Pancreatic Cancer Moon Shot Program and the Khalifa Bin Zayed Foundation to A.M.; the Human Breast Cell Atlas Seed Network Grant HCA3-0000000147 from the Chan Zuckerberg Initiative to K.C.; the NIH K22 CA234406-01 and the Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research to J.P.S.; a gift from the Feinberg Family and MD Anderson Cancer Center Pre-Cancer Atlas Project to E.V.; the MD Anderson Colorectal Cancer Moon Shot Program to S.K. and E.V.; the NIH T32 CA009599 to J.J.L.; the NIH/NCI P30 CA016672 to the MD Anderson Cancer Center Core Support Grant; and the CPRIT SINGLE CORE Facilities Grant RP180684. Acknowledgments: We thank Charles Bowen for performing single cell dissociations from colonic samples, Kangyu Lin and Jinzhuang Dou for assistance in data acquisition and transfer, and the Single Cell Core at MD Anderson Cancer Center. Funding Information: Funding: This work was supported by the MD Anderson Pancreatic Cancer Moon Shot Program and the Khalifa Bin Zayed Foundation to A.M.; the Human Breast Cell Atlas Seed Network Grant HCA3-0000000147 from the Chan Zuckerberg Initiative to K.C.; the NIH K22 CA234406-01 and the Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research to J.P.S.; a gift from the Feinberg Family and MD Anderson Cancer Center Pre-Cancer Atlas Project to E.V.; the MD Anderson Colorectal Cancer Moon Shot Program to S.K. and E.V.; the NIH T32 CA009599 to J.J.L.; the NIH/NCI P30 CA016672 to the MD Anderson Cancer Center Core Support Grant; and the CPRIT SINGLE CORE Facilities Grant RP180684. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = jun,
doi = "10.3390/genes11060645",
language = "English (US)",
volume = "11",
pages = "1--9",
journal = "Genes",
issn = "2073-4425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}