Repair but not potentiation observed in mouse lung irradiated with neon ions

E. L. Travis; S. B. Curtis; J. Howard; J. F. Fowler

doi:10.2307/3577102

Repair but not potentiation observed in mouse lung irradiated with neon ions

E. L. Travis, S. B. Curtis, J. Howard, J. F. Fowler

Experimental Radiation Oncology

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3 Scopus citations

Abstract

The lungs of mice were irradiated with 1, 4, or 7 fractions of X rays or neon ions in a 4-cm spread Bragg peak. Lung function as a function of total radiation dose was tested at 7 and 12 months after irradiation by measuring the resting breathing rate in a whole-body plethysmograph. The isoeffect doses increased sequentially with X rays for 1 through 4 to 7 fractions, demonstrating repair of sublethal radiation injury as previously reported. There was also a significant increase of isoeffect dose with neon ions between 1 and 4 fractions but no further increase at 7 fractions. Thus repair instead of potentiation of radiation injury in lung clearly occurred after neon ion irradiation. The effectiveness of neon ions appeared to be closer to that of neutrons with a mean energy of 8 meV than those with a mean energy of 2.3 meV.

Original language	English (US)
Pages (from-to)	500-507
Number of pages	8
Journal	Radiation research
Volume	112
Issue number	3
DOIs	https://doi.org/10.2307/3577102
State	Published - 1987

ASJC Scopus subject areas

Radiation
Biophysics
Radiology Nuclear Medicine and imaging

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@article{977e900234eb464eb04759b37c756dbb,

title = "Repair but not potentiation observed in mouse lung irradiated with neon ions",

abstract = "The lungs of mice were irradiated with 1, 4, or 7 fractions of X rays or neon ions in a 4-cm spread Bragg peak. Lung function as a function of total radiation dose was tested at 7 and 12 months after irradiation by measuring the resting breathing rate in a whole-body plethysmograph. The isoeffect doses increased sequentially with X rays for 1 through 4 to 7 fractions, demonstrating repair of sublethal radiation injury as previously reported. There was also a significant increase of isoeffect dose with neon ions between 1 and 4 fractions but no further increase at 7 fractions. Thus repair instead of potentiation of radiation injury in lung clearly occurred after neon ion irradiation. The effectiveness of neon ions appeared to be closer to that of neutrons with a mean energy of 8 meV than those with a mean energy of 2.3 meV.",

author = "Travis, {E. L.} and Curtis, {S. B.} and J. Howard and Fowler, {J. F.}",

note = "Funding Information: Financial support from FCT/MCTES (Portugal) through projects EXCL/QEQ-PRS/0308/2012, PTDC/AAC-AMB/108849/2008, PTDC/ CTM/104782/2008 is gratefully acknowledged. The authors also acknowledge FCT/MCTES for financial support through grant SFRH/BPD/103533/2014 (Rui P. P. L. Ribeiro) and FCT Investigator contract IF/01016/2014 (Isabel A. A. C. Esteves). This work was partially supported by the Associate Laboratory Research Unit for Green Chemistry - Technologies and Processes Clean - LAQV which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265).",

year = "1987",

doi = "10.2307/3577102",

language = "English (US)",

volume = "112",

pages = "500--507",

journal = "Radiation research",

issn = "0033-7587",

publisher = "Radiation Research Society",

number = "3",

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T1 - Repair but not potentiation observed in mouse lung irradiated with neon ions

AU - Travis, E. L.

AU - Curtis, S. B.

AU - Howard, J.

AU - Fowler, J. F.

N1 - Funding Information: Financial support from FCT/MCTES (Portugal) through projects EXCL/QEQ-PRS/0308/2012, PTDC/AAC-AMB/108849/2008, PTDC/ CTM/104782/2008 is gratefully acknowledged. The authors also acknowledge FCT/MCTES for financial support through grant SFRH/BPD/103533/2014 (Rui P. P. L. Ribeiro) and FCT Investigator contract IF/01016/2014 (Isabel A. A. C. Esteves). This work was partially supported by the Associate Laboratory Research Unit for Green Chemistry - Technologies and Processes Clean - LAQV which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265).

PY - 1987

Y1 - 1987

N2 - The lungs of mice were irradiated with 1, 4, or 7 fractions of X rays or neon ions in a 4-cm spread Bragg peak. Lung function as a function of total radiation dose was tested at 7 and 12 months after irradiation by measuring the resting breathing rate in a whole-body plethysmograph. The isoeffect doses increased sequentially with X rays for 1 through 4 to 7 fractions, demonstrating repair of sublethal radiation injury as previously reported. There was also a significant increase of isoeffect dose with neon ions between 1 and 4 fractions but no further increase at 7 fractions. Thus repair instead of potentiation of radiation injury in lung clearly occurred after neon ion irradiation. The effectiveness of neon ions appeared to be closer to that of neutrons with a mean energy of 8 meV than those with a mean energy of 2.3 meV.

AB - The lungs of mice were irradiated with 1, 4, or 7 fractions of X rays or neon ions in a 4-cm spread Bragg peak. Lung function as a function of total radiation dose was tested at 7 and 12 months after irradiation by measuring the resting breathing rate in a whole-body plethysmograph. The isoeffect doses increased sequentially with X rays for 1 through 4 to 7 fractions, demonstrating repair of sublethal radiation injury as previously reported. There was also a significant increase of isoeffect dose with neon ions between 1 and 4 fractions but no further increase at 7 fractions. Thus repair instead of potentiation of radiation injury in lung clearly occurred after neon ion irradiation. The effectiveness of neon ions appeared to be closer to that of neutrons with a mean energy of 8 meV than those with a mean energy of 2.3 meV.

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Repair but not potentiation observed in mouse lung irradiated with neon ions

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