Requirement for liml in head-organizer function

William Shawlot; Richard R. Behringer

doi:10.1038/374425a0

Requirement for liml in head-organizer function

William Shawlot, Richard R. Behringer

Genetics

Research output: Contribution to journal › Article › peer-review

694 Scopus citations

Abstract

Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.

Original language	English (US)
Pages (from-to)	425-430
Number of pages	6
Journal	Nature
Volume	374
Issue number	6521
DOIs	https://doi.org/10.1038/374425a0
State	Published - Mar 30 1995

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title = "Requirement for liml in head-organizer function",

abstract = "Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.",

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N2 - Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.

AB - Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.

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Requirement for liml in head-organizer function

Abstract

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