Abstract
The Bcr-Abl oncoprotein causes chronic myeloid leukemia by a mechanism involving its activated tyrosine kinase. BCR-ABL+ mouse hematopoietic cells persistently express and secrete lipocalin 2 by a mechanism that requires the tyrosine kinase of the Bcr-Abl oncoprotein. Our new findings indicate that lipocalin 2 is required for leukemia induction, as prevention of expression of lipocalin 2 by BCR-ABL+ mouse marrow cells totally blocks leukemia induction in a mouse model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 600-603 |
| Number of pages | 4 |
| Journal | Leukemia and Lymphoma |
| Volume | 49 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2008 |
Keywords
- Bcr-Abl
- Chronic myeloid leukemia
- Lipocalin 2
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research