Abstract
The D-elg gene encodes an ETS domain transcription factor that functions in Drosophila oogenesis. D-elg belongs to a small group of genes that are required for the formation of both the anteroposterior and dorsoventral axes of the egg chamber. During oogenesis in D-elg mutant females, the spatial localization of oskar and gurken mRNAs in the oocyte is disrupted and a follicle cell enhancer trap marker identifies dorsoventral polarity defects. Also, specialized follicle cells, called border cells, fail to migrate from their anterior location to a position adjacent to the developing oocyte. Consistent with these phenotypes, D-elg shows genetic interactions with two genes required for normal egg chamber differentiation.
Original language | English (US) |
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Pages (from-to) | 1033-1040 |
Number of pages | 8 |
Journal | Oncogene |
Volume | 11 |
Issue number | 6 |
State | Published - Sep 21 1995 |
Keywords
- Cell migration
- Drosophila oogenesis
- Mutant phenotype
- Transcription factor
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research