Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia

Estella Whimbey; Robert B. Couch; Janet A. Englund; Michael Andreeff; James M. Goodrich; Issam I. Raad; Victor Lewis; Nadeem Mirza; Mario A. Luna; Barbara Baxter; Jeffrey J. Tarrand; Gerald P. Bodey

doi:10.1093/clinids/21.2.376

Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia

Estella Whimbey, Robert B. Couch, Janet A. Englund, Michael Andreeff, James M. Goodrich, Issam I. Raad, Victor Lewis, Nadeem Mirza, Mario A. Luna, Barbara Baxter, Jeffrey J. Tarrand, Gerald P. Bodey

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131 Scopus citations

Abstract

Respiratory syncytial virus (RSV) has been demonstrated to be an important cause of life-threatening pneumonia in adult bone marrow transplant recipients; however, its role in other immunocom-promised adults has not been defined. We prospectively studied all adult patients with leukemia who were hospitalized at M. D. Anderson Cancer Center (Houston) during a 1-year period (November 1993 through October 1994). During a 19-week period when RSV was prevalent in the community, it was isolated from 9 (10%) of 87 patients with leukemia who developed an acute respiratory illness. In 6 (75%) of 8 patients with profound chemotherapy-induced myelosuppression, the RSV infection was complicated by pneumonia, with an 83% mortality rate. RSV appears to be an important cause of severe and often fatal pneumonia in myelosuppressed patients with leukemia.

Original language	English (US)
Pages (from-to)	376-379
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	21
Issue number	2
DOIs	https://doi.org/10.1093/clinids/21.2.376
State	Published - Aug 1995

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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title = "Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia",

abstract = "Respiratory syncytial virus (RSV) has been demonstrated to be an important cause of life-threatening pneumonia in adult bone marrow transplant recipients; however, its role in other immunocom-promised adults has not been defined. We prospectively studied all adult patients with leukemia who were hospitalized at M. D. Anderson Cancer Center (Houston) during a 1-year period (November 1993 through October 1994). During a 19-week period when RSV was prevalent in the community, it was isolated from 9 (10%) of 87 patients with leukemia who developed an acute respiratory illness. In 6 (75%) of 8 patients with profound chemotherapy-induced myelosuppression, the RSV infection was complicated by pneumonia, with an 83% mortality rate. RSV appears to be an important cause of severe and often fatal pneumonia in myelosuppressed patients with leukemia.",

author = "Estella Whimbey and Couch, {Robert B.} and Englund, {Janet A.} and Michael Andreeff and Goodrich, {James M.} and Raad, {Issam I.} and Victor Lewis and Nadeem Mirza and Luna, {Mario A.} and Barbara Baxter and Tarrand, {Jeffrey J.} and Bodey, {Gerald P.}",

note = "Funding Information: Received 9 January 1995; revised 15 March 1995. This work was presented in part at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy held on 4-7 October 1994 in Orlando, Florida. Financial support: This work was supported in part by Public Health Service contract NOIAI-15103 from the National Institute of Allergy and Infectious Diseases. Reprints or correspondence: Dr. Estella Whimbey, Section of Infectious Diseases, Box 47, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030.",

year = "1995",

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doi = "10.1093/clinids/21.2.376",

language = "English (US)",

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pages = "376--379",

journal = "Clinical Infectious Diseases",

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T1 - Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia

AU - Whimbey, Estella

AU - Couch, Robert B.

AU - Englund, Janet A.

AU - Andreeff, Michael

AU - Goodrich, James M.

AU - Raad, Issam I.

AU - Lewis, Victor

AU - Mirza, Nadeem

AU - Luna, Mario A.

AU - Baxter, Barbara

AU - Tarrand, Jeffrey J.

AU - Bodey, Gerald P.

N1 - Funding Information: Received 9 January 1995; revised 15 March 1995. This work was presented in part at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy held on 4-7 October 1994 in Orlando, Florida. Financial support: This work was supported in part by Public Health Service contract NOIAI-15103 from the National Institute of Allergy and Infectious Diseases. Reprints or correspondence: Dr. Estella Whimbey, Section of Infectious Diseases, Box 47, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030.

PY - 1995/8

Y1 - 1995/8

N2 - Respiratory syncytial virus (RSV) has been demonstrated to be an important cause of life-threatening pneumonia in adult bone marrow transplant recipients; however, its role in other immunocom-promised adults has not been defined. We prospectively studied all adult patients with leukemia who were hospitalized at M. D. Anderson Cancer Center (Houston) during a 1-year period (November 1993 through October 1994). During a 19-week period when RSV was prevalent in the community, it was isolated from 9 (10%) of 87 patients with leukemia who developed an acute respiratory illness. In 6 (75%) of 8 patients with profound chemotherapy-induced myelosuppression, the RSV infection was complicated by pneumonia, with an 83% mortality rate. RSV appears to be an important cause of severe and often fatal pneumonia in myelosuppressed patients with leukemia.

AB - Respiratory syncytial virus (RSV) has been demonstrated to be an important cause of life-threatening pneumonia in adult bone marrow transplant recipients; however, its role in other immunocom-promised adults has not been defined. We prospectively studied all adult patients with leukemia who were hospitalized at M. D. Anderson Cancer Center (Houston) during a 1-year period (November 1993 through October 1994). During a 19-week period when RSV was prevalent in the community, it was isolated from 9 (10%) of 87 patients with leukemia who developed an acute respiratory illness. In 6 (75%) of 8 patients with profound chemotherapy-induced myelosuppression, the RSV infection was complicated by pneumonia, with an 83% mortality rate. RSV appears to be an important cause of severe and often fatal pneumonia in myelosuppressed patients with leukemia.

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Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia

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