Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle

H. Rodney Withers; K. Mason; B. O. Reid; N. Dubravsky; H. T. Barkley; B. W. Brown; J. B. Smathers

doi:10.1002/1097-0142(197407)34:1<39::AID-CNCR2820340107>3.0.CO;2-Z

Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle

H. Rodney Withers, K. Mason, B. O. Reid, N. Dubravsky, H. T. Barkley, B. W. Brown, J. B. Smathers

Experimental Radiation Oncology

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101 Scopus citations

Abstract

Using an assay for jejunal crypt stem cell survival, the biological effectiveness of two cyclotron‐produced neutron beams relative to one another and to ⁶⁰Co γ‐radiation has been determined at doses of the order used per fraction in clinical trials of neutrons. Dose survival curves were determined using up to 5 doses of neutrons and up to 20 dose‐fractions of γ rays. There is little sparing of jejunal mucosa as a result of repair of sublethal injury during intervals between neutron dose fractions, whereas such repair is considerable when γ‐ray doses are fractionated. The response of jejunal crypt stem cells to both neutron and gamma radiation shows considerable variation throughout the division cycle, but the variation is less with neutrons.

Original language	English (US)
Pages (from-to)	39-47
Number of pages	9
Journal	Cancer
Volume	34
Issue number	1
DOIs	https://doi.org/10.1002/1097-0142(197407)34:1<39::AID-CNCR2820340107>3.0.CO;2-Z
State	Published - Jul 1974

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(197407)34:1<39::AID-CNCR2820340107>3.0.CO;2-Z

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title = "Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle",

abstract = "Using an assay for jejunal crypt stem cell survival, the biological effectiveness of two cyclotron‐produced neutron beams relative to one another and to 60Co γ‐radiation has been determined at doses of the order used per fraction in clinical trials of neutrons. Dose survival curves were determined using up to 5 doses of neutrons and up to 20 dose‐fractions of γ rays. There is little sparing of jejunal mucosa as a result of repair of sublethal injury during intervals between neutron dose fractions, whereas such repair is considerable when γ‐ray doses are fractionated. The response of jejunal crypt stem cells to both neutron and gamma radiation shows considerable variation throughout the division cycle, but the variation is less with neutrons.",

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T1 - Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle

AU - Rodney Withers, H.

AU - Mason, K.

AU - Reid, B. O.

AU - Dubravsky, N.

AU - Barkley, H. T.

AU - Brown, B. W.

AU - Smathers, J. B.

PY - 1974/7

Y1 - 1974/7

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AB - Using an assay for jejunal crypt stem cell survival, the biological effectiveness of two cyclotron‐produced neutron beams relative to one another and to 60Co γ‐radiation has been determined at doses of the order used per fraction in clinical trials of neutrons. Dose survival curves were determined using up to 5 doses of neutrons and up to 20 dose‐fractions of γ rays. There is little sparing of jejunal mucosa as a result of repair of sublethal injury during intervals between neutron dose fractions, whereas such repair is considerable when γ‐ray doses are fractionated. The response of jejunal crypt stem cells to both neutron and gamma radiation shows considerable variation throughout the division cycle, but the variation is less with neutrons.

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Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle

Abstract

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