TY - JOUR
T1 - Retinoid Chemoprevention of Aerodigestive Cancer
T2 - From Basic Research to the Clinic
AU - Hong, Waun Ki
AU - Lippman, Scott M.
AU - Hittelman, Walter N.
AU - Lotan, Reuben
PY - 1995/7/1
Y1 - 1995/7/1
N2 - Epithelial cancers in the lung and head and neck are a devastating group of diseases which account for approximately 35% of cancer deaths in the United States. Chemoprevention is a new strategy to block or reverse the carcinogenic process. Biological concepts including field carcinogenesis and multistep carcinogenesis strongly support the rationale for using chemopreventive approaches. Our group has focused on applications of translational retinoid studies to increase our knowledge of the molecular events in biology and chemoprevention. In this review, we will focus on four issues, biology, retinoids, retinoid clinical trials, and translational research, in the chemoprevention of aerodigestive cancers.
AB - Epithelial cancers in the lung and head and neck are a devastating group of diseases which account for approximately 35% of cancer deaths in the United States. Chemoprevention is a new strategy to block or reverse the carcinogenic process. Biological concepts including field carcinogenesis and multistep carcinogenesis strongly support the rationale for using chemopreventive approaches. Our group has focused on applications of translational retinoid studies to increase our knowledge of the molecular events in biology and chemoprevention. In this review, we will focus on four issues, biology, retinoids, retinoid clinical trials, and translational research, in the chemoprevention of aerodigestive cancers.
UR - http://www.scopus.com/inward/record.url?scp=0029008108&partnerID=8YFLogxK
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M3 - Article
C2 - 9816032
AN - SCOPUS:0029008108
SN - 1078-0432
VL - 1
SP - 677
EP - 686
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 7
ER -