TY - JOUR
T1 - Retinoid-mediated signaling pathways in CD38 antigen expression in myeloid leukemia cells
AU - Mehta, Kapil
AU - Cheema, Sangeeta
N1 - Funding Information:
The work in authors' laboratory was supported by grants from the Texas Higher Education Coordinating Board (ATP000015-012) and the Food and Drug Administration (FDR-000923). We would like to thank Mr. Jude Richard for editorial assistance.
PY - 1999
Y1 - 1999
N2 - The lymphocyte cell surface antigen CD38, which was originally described as a differentiation marker, has emerged as an important multifunctional protein. Its most intriguing and well characterized function is its ability to catalyze the synthesis of cyclic ADP-ribose (cADPR) from NAD. cADPR serves as an important second messenger in controlling the release of intracellular calcium from ryanodine-sensitive intracellular pools. By virtue of its ability to synthesize cADPR as well as to act as an adhesion and signal transduction molecule, CD38 may play a role in such diverse physiological processes as cell growth, apoptosis, differentiation, and inflammation. Equally interesting is the pattern of CD38 expression in hematopoeitic cells. In the bone marrow, early precursor cells predominantly express CD38 antigen, whereas mature circulating blood cells lack or express very low levels. The expression is also high on malignant hematopoeitic cells and thus may be of prognostic relevance in certain leukemias. Presently, there is little information available on the factors that regulate the expresssion of CD38 antigen in hematopoeitic cells. In this review, we summarize recent findings on the regulation of CD38 antigen by retinoids (vitamin A and related compounds). At least in the myeloid cell lineage, retinoids appear to be exquisitely potent and specific inducers of CD38 antigen expression, and retinoid-induced expression of CD38 is mediated via activation of the retinoic acid-alpha (RARα) nuclear receptor.
AB - The lymphocyte cell surface antigen CD38, which was originally described as a differentiation marker, has emerged as an important multifunctional protein. Its most intriguing and well characterized function is its ability to catalyze the synthesis of cyclic ADP-ribose (cADPR) from NAD. cADPR serves as an important second messenger in controlling the release of intracellular calcium from ryanodine-sensitive intracellular pools. By virtue of its ability to synthesize cADPR as well as to act as an adhesion and signal transduction molecule, CD38 may play a role in such diverse physiological processes as cell growth, apoptosis, differentiation, and inflammation. Equally interesting is the pattern of CD38 expression in hematopoeitic cells. In the bone marrow, early precursor cells predominantly express CD38 antigen, whereas mature circulating blood cells lack or express very low levels. The expression is also high on malignant hematopoeitic cells and thus may be of prognostic relevance in certain leukemias. Presently, there is little information available on the factors that regulate the expresssion of CD38 antigen in hematopoeitic cells. In this review, we summarize recent findings on the regulation of CD38 antigen by retinoids (vitamin A and related compounds). At least in the myeloid cell lineage, retinoids appear to be exquisitely potent and specific inducers of CD38 antigen expression, and retinoid-induced expression of CD38 is mediated via activation of the retinoic acid-alpha (RARα) nuclear receptor.
KW - Cell surface antigen
KW - Glycohydrolase
KW - Retinoids
KW - Signal transduction
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U2 - 10.3109/10428199909058401
DO - 10.3109/10428199909058401
M3 - Review article
C2 - 10048416
AN - SCOPUS:0033054588
SN - 1042-8194
VL - 32
SP - 441
EP - 449
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5-6
ER -