Abstract
Reversed liver spleen scintigraphic brightness was observed in 25 patients during consecutive liver spleen imaging. Eighteen had solid neoplasms, while 9 had melanoma. Mouse liver spleen distributions of technetium sulfur colloid confirmed earlier reports; however, in 4 human subjects the spleen received more colloid than the liver on a weight basis. Liver spleen phantom studies predicted that the activity concentration ratio of spleen to liver exceeds 3.7:1 when the spleen appears scintigraphically brighter than the liver. Our data suggest it is not blood flow that accounts for greater splenic than liver accumulation of colloid. Implications of an immunologic phenomenon are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-27 |
| Number of pages | 9 |
| Journal | RES Journal of the Reticuloendothelial Society |
| Volume | 19 |
| Issue number | 1 |
| State | Published - 1976 |
ASJC Scopus subject areas
- Hematology