Reversible neurotoxicity of interleukin-2 and tumor necrosis factor: Correlation of SPECT with neuropsychological testing

C. A. Meyers; A. D. Valentine; F. C.L. Wong; N. E. Leeds

doi:10.1176/jnp.6.3.285

Reversible neurotoxicity of interleukin-2 and tumor necrosis factor: Correlation of SPECT with neuropsychological testing

C. A. Meyers, A. D. Valentine, F. C.L. Wong, N. E. Leeds

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A 41-year-old man developed subacute neurotoxicity associated with interleukin-2 and tumor necrosis factor therapy for metastatic renal cell carcinoma. Cognitive deficits revealed on neuropsychological testing and frontal lobe perfusion deficits revealed on SPECT resolved after 1 month. Findings suggest possible neuroanatomic and physiologic substrates of cytokine neurotoxicity.

Original language	English (US)
Pages (from-to)	285-288
Number of pages	4
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	6
Issue number	3
DOIs	https://doi.org/10.1176/jnp.6.3.285
State	Published - 1994

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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abstract = "A 41-year-old man developed subacute neurotoxicity associated with interleukin-2 and tumor necrosis factor therapy for metastatic renal cell carcinoma. Cognitive deficits revealed on neuropsychological testing and frontal lobe perfusion deficits revealed on SPECT resolved after 1 month. Findings suggest possible neuroanatomic and physiologic substrates of cytokine neurotoxicity.",

author = "Meyers, {C. A.} and Valentine, {A. D.} and Wong, {F. C.L.} and Leeds, {N. E.}",

year = "1994",

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AU - Leeds, N. E.

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AB - A 41-year-old man developed subacute neurotoxicity associated with interleukin-2 and tumor necrosis factor therapy for metastatic renal cell carcinoma. Cognitive deficits revealed on neuropsychological testing and frontal lobe perfusion deficits revealed on SPECT resolved after 1 month. Findings suggest possible neuroanatomic and physiologic substrates of cytokine neurotoxicity.

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Reversible neurotoxicity of interleukin-2 and tumor necrosis factor: Correlation of SPECT with neuropsychological testing

Abstract

ASJC Scopus subject areas

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