TY - JOUR
T1 - Reversible Ureteral Obstruction due to Polyomavirus Infection after Percutaneous Nephrostomy Catheter Placement
AU - Khan, Hassan
AU - Oberoi, Shilpa
AU - Mahvash, Armeen
AU - Sharma, Manish
AU - Rondon, Gabriela
AU - Alousi, Amin
AU - Shpall, Elizabeth J.
AU - Kontoyiannis, Dimitrios P.
AU - Champlin, Richard E.
AU - Ciurea, Stefan O.
PY - 2011/10
Y1 - 2011/10
N2 - BK virus (BKV) is a human polyomavirus that remains latent in the urinary tract epithelium in most individuals. However, in immunocompromised states, including after hematopoietic stem cell transplantation (HSCT), BKV may reactivate and cause infection predominantly affecting the bladder, commonly manifested as hemorrhagic cystitis. Renal insufficiency, occasionally requiring hemodialysis, is not uncommon and was previously attributed to medications or the development of tubulointestitial nephritis. We report a series of 6 HSCT recipients who developed obstructive uropathy of the upper urinary tract system secondary to inflammation and hemorrhage involving the upper uroepithelium, causing ureteral stenosis. Temporary placement of a percutaneous nephrostomy catheter relieved the obstruction and significantly improved kidney function, successfully preventing progression to more advanced renal disease in these patients.
AB - BK virus (BKV) is a human polyomavirus that remains latent in the urinary tract epithelium in most individuals. However, in immunocompromised states, including after hematopoietic stem cell transplantation (HSCT), BKV may reactivate and cause infection predominantly affecting the bladder, commonly manifested as hemorrhagic cystitis. Renal insufficiency, occasionally requiring hemodialysis, is not uncommon and was previously attributed to medications or the development of tubulointestitial nephritis. We report a series of 6 HSCT recipients who developed obstructive uropathy of the upper urinary tract system secondary to inflammation and hemorrhage involving the upper uroepithelium, causing ureteral stenosis. Temporary placement of a percutaneous nephrostomy catheter relieved the obstruction and significantly improved kidney function, successfully preventing progression to more advanced renal disease in these patients.
KW - Allogeneic stem cell transplantation
KW - BK virus infection
KW - Obstructive nephropathy
UR - http://www.scopus.com/inward/record.url?scp=80052967113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052967113&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2011.03.002
DO - 10.1016/j.bbmt.2011.03.002
M3 - Article
C2 - 21396475
AN - SCOPUS:80052967113
SN - 1083-8791
VL - 17
SP - 1551
EP - 1555
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 10
ER -