Review of the Tumor Microenvironment in Basal and Squamous Cell Carcinoma

Elizabeth Chiang; Haleigh Stafford; Jane Buell; Uma Ramesh; Moran Amit; Priyadharsini Nagarajan; Michael Migden; Dan Yaniv

doi:10.3390/cancers15092453

Review of the Tumor Microenvironment in Basal and Squamous Cell Carcinoma

Elizabeth Chiang, Haleigh Stafford, Jane Buell, Uma Ramesh, Moran Amit, Priyadharsini Nagarajan, Michael Migden, Dan Yaniv

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

It is widely known that tumor cells of basal and squamous cell carcinoma interact with the cellular and acellular components of the tumor microenvironment to promote tumor growth and progression. While this environment differs for basal and squamous cell carcinoma, the cellular players within both create an immunosuppressed environment by downregulating effector CD4+ and CD8+ T cells and promoting the release of pro-oncogenic Th2 cytokines. Understanding the crosstalk that occurs within the tumor microenvironment has led to the development of immunotherapeutic agents, including vismodegib and cemiplimab to treat BCC and SCC, respectively. However, further investigation of the TME will provide the opportunity to discover novel treatment options.

Original language	English (US)
Article number	2453
Journal	Cancers
Volume	15
Issue number	9
DOIs	https://doi.org/10.3390/cancers15092453
State	Published - May 2023

Keywords

basal cell carcinoma
immunotherapy
squamous cell carcinoma
tumor microenvironment

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers15092453

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title = "Review of the Tumor Microenvironment in Basal and Squamous Cell Carcinoma",

abstract = "It is widely known that tumor cells of basal and squamous cell carcinoma interact with the cellular and acellular components of the tumor microenvironment to promote tumor growth and progression. While this environment differs for basal and squamous cell carcinoma, the cellular players within both create an immunosuppressed environment by downregulating effector CD4+ and CD8+ T cells and promoting the release of pro-oncogenic Th2 cytokines. Understanding the crosstalk that occurs within the tumor microenvironment has led to the development of immunotherapeutic agents, including vismodegib and cemiplimab to treat BCC and SCC, respectively. However, further investigation of the TME will provide the opportunity to discover novel treatment options.",

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AU - Stafford, Haleigh

AU - Buell, Jane

AU - Ramesh, Uma

AU - Amit, Moran

AU - Nagarajan, Priyadharsini

AU - Migden, Michael

AU - Yaniv, Dan

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N2 - It is widely known that tumor cells of basal and squamous cell carcinoma interact with the cellular and acellular components of the tumor microenvironment to promote tumor growth and progression. While this environment differs for basal and squamous cell carcinoma, the cellular players within both create an immunosuppressed environment by downregulating effector CD4+ and CD8+ T cells and promoting the release of pro-oncogenic Th2 cytokines. Understanding the crosstalk that occurs within the tumor microenvironment has led to the development of immunotherapeutic agents, including vismodegib and cemiplimab to treat BCC and SCC, respectively. However, further investigation of the TME will provide the opportunity to discover novel treatment options.

AB - It is widely known that tumor cells of basal and squamous cell carcinoma interact with the cellular and acellular components of the tumor microenvironment to promote tumor growth and progression. While this environment differs for basal and squamous cell carcinoma, the cellular players within both create an immunosuppressed environment by downregulating effector CD4+ and CD8+ T cells and promoting the release of pro-oncogenic Th2 cytokines. Understanding the crosstalk that occurs within the tumor microenvironment has led to the development of immunotherapeutic agents, including vismodegib and cemiplimab to treat BCC and SCC, respectively. However, further investigation of the TME will provide the opportunity to discover novel treatment options.

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KW - immunotherapy

KW - squamous cell carcinoma

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Review of the Tumor Microenvironment in Basal and Squamous Cell Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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