Rictor encounters RhoGDI2: The second pilot is taking a lead

Nitin K. Agarwal; Dubek Kazyken; Dos D. Sarbassov

doi:10.4161/sgtp.23346

Rictor encounters RhoGDI2: The second pilot is taking a lead

Nitin K. Agarwal, Dubek Kazyken, Dos D. Sarbassov

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Rictor's role in cell migration has been first indicated in the original chemotaxis studies in Dictyostelium and more recent studies reported that rictor is required for migration of cancer cells. How rictor promotes cell migration remains poorly characterized. Based on our proteomics study we have identified a novel functional role of rictor in regulation of cell migration. Here, we discuss our recent finding that rictor by suppressing RhoGDI2 maintains activity of the Rac1/cdc42 GTPases and promotes cell migration. Our finding outlines a critical role of rictor in the regulation of RhoGDI2 activity. This study opens new avenues in the investigation of cancer metastasis by analyzing the rictor dependent post-translational modification of RhoGDI2.

Original language	English (US)
Pages (from-to)	102-105
Number of pages	4
Journal	Small GTPases
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/sgtp.23346
State	Published - 2013

Keywords

Cell migration
Rac1
Rho GTPases
RhoGDI2
Rictor

ASJC Scopus subject areas

Biochemistry
Cell Biology

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10.4161/sgtp.23346

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title = "Rictor encounters RhoGDI2: The second pilot is taking a lead",

abstract = "Rictor's role in cell migration has been first indicated in the original chemotaxis studies in Dictyostelium and more recent studies reported that rictor is required for migration of cancer cells. How rictor promotes cell migration remains poorly characterized. Based on our proteomics study we have identified a novel functional role of rictor in regulation of cell migration. Here, we discuss our recent finding that rictor by suppressing RhoGDI2 maintains activity of the Rac1/cdc42 GTPases and promotes cell migration. Our finding outlines a critical role of rictor in the regulation of RhoGDI2 activity. This study opens new avenues in the investigation of cancer metastasis by analyzing the rictor dependent post-translational modification of RhoGDI2.",

keywords = "Cell migration, Rac1, Rho GTPases, RhoGDI2, Rictor",

author = "Agarwal, {Nitin K.} and Dubek Kazyken and Sarbassov, {Dos D.}",

note = "Funding Information: This study was supported by the MD Anderson Metastasis Research Center and the NIH grants CA133522 (DDS).",

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doi = "10.4161/sgtp.23346",

language = "English (US)",

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journal = "Small GTPases",

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publisher = "Landes Bioscience",

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T1 - Rictor encounters RhoGDI2

T2 - The second pilot is taking a lead

AU - Agarwal, Nitin K.

AU - Kazyken, Dubek

AU - Sarbassov, Dos D.

N1 - Funding Information: This study was supported by the MD Anderson Metastasis Research Center and the NIH grants CA133522 (DDS).

PY - 2013

Y1 - 2013

N2 - Rictor's role in cell migration has been first indicated in the original chemotaxis studies in Dictyostelium and more recent studies reported that rictor is required for migration of cancer cells. How rictor promotes cell migration remains poorly characterized. Based on our proteomics study we have identified a novel functional role of rictor in regulation of cell migration. Here, we discuss our recent finding that rictor by suppressing RhoGDI2 maintains activity of the Rac1/cdc42 GTPases and promotes cell migration. Our finding outlines a critical role of rictor in the regulation of RhoGDI2 activity. This study opens new avenues in the investigation of cancer metastasis by analyzing the rictor dependent post-translational modification of RhoGDI2.

AB - Rictor's role in cell migration has been first indicated in the original chemotaxis studies in Dictyostelium and more recent studies reported that rictor is required for migration of cancer cells. How rictor promotes cell migration remains poorly characterized. Based on our proteomics study we have identified a novel functional role of rictor in regulation of cell migration. Here, we discuss our recent finding that rictor by suppressing RhoGDI2 maintains activity of the Rac1/cdc42 GTPases and promotes cell migration. Our finding outlines a critical role of rictor in the regulation of RhoGDI2 activity. This study opens new avenues in the investigation of cancer metastasis by analyzing the rictor dependent post-translational modification of RhoGDI2.

KW - Cell migration

KW - Rac1

KW - Rho GTPases

KW - RhoGDI2

KW - Rictor

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ER -

Rictor encounters RhoGDI2: The second pilot is taking a lead

Abstract

Keywords

ASJC Scopus subject areas

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