TY - JOUR
T1 - Risk factors for Candida tropicalis fungemia in patients with cancer
AU - Kontoyiannis, D. P.
AU - Vaziri, I.
AU - Hanna, H. A.
AU - Boktour, M.
AU - Thornby, J.
AU - Hachem, R.
AU - Bodey, G. P.
AU - Raad, I. I.
PY - 2001/11
Y1 - 2001/11
N2 - The risk factors for and presentation of Candida tropicalis fungemia, in comparison with those of Candida albicans, have been incompletely characterized. We compared 43 cases of C. tropicalis fungemia with 148 cases of C. albicans fungemia. In univariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .0006), prolonged neutropenia (P = .03), and a positive blood culture for more days (P = .02). The 2 groups did not differ with regard to baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of catheter-associated fungemia, or response to antifungals. In multivariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .02), previous neutropenia (P = .002), and a longer stay in the intensive care unit during the infectious episode (P = .01). Also, the response of the breakthrough C. tropicalis fungemia was lower (P = .05). In conclusion, the host determinants associated with susceptibility to C. tropicalis are leukemia and prolonged neutropenia.
AB - The risk factors for and presentation of Candida tropicalis fungemia, in comparison with those of Candida albicans, have been incompletely characterized. We compared 43 cases of C. tropicalis fungemia with 148 cases of C. albicans fungemia. In univariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .0006), prolonged neutropenia (P = .03), and a positive blood culture for more days (P = .02). The 2 groups did not differ with regard to baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of catheter-associated fungemia, or response to antifungals. In multivariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .02), previous neutropenia (P = .002), and a longer stay in the intensive care unit during the infectious episode (P = .01). Also, the response of the breakthrough C. tropicalis fungemia was lower (P = .05). In conclusion, the host determinants associated with susceptibility to C. tropicalis are leukemia and prolonged neutropenia.
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U2 - 10.1086/323812
DO - 10.1086/323812
M3 - Article
C2 - 11568858
AN - SCOPUS:0035889586
SN - 1058-4838
VL - 33
SP - 1676
EP - 1681
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 10
ER -