@article{7d36c554188849d592c484289d7c5bb6,
title = "Risk of radiation-related subsequent malignant tumors in survivors of Ewing{\textquoteright}s sarcoma",
abstract = "Twenty-four long-term survivors of Ewing{\textquoteright}s sarcoma were Identified as being at risk for a second primary tumor. Among this group of patients followed from 3 to 22 years, 4 new bone tumors were observed, whereas 1.2×10-3 were expected. All new tumors arose in heavily irradiated areas. The risk associated with radiation after 3 years was 7.2 cases/million person-years per rad. The cumulative cancer risk over 10 years for Irradiated patients was 35% (SE, 15.1%). Intensive chemotherapy (cyclophosphamide and vincristine administered in five or more courses) seemed to exert an enhancing effect, increasing the rate of development of new tumors.",
author = "Strong, {Louise C.} and Jay Herson and Osborne, {Barbara M.} and Sutow, {Wataru W.}",
note = "Funding Information: 1 Received August 7, 1978; accepted November 27, 1978. 2 Supported in part by Public Health Service grants GM19513-C9 from the National Institute of General Medical Sciences and CAI1430 from the National Cancer Institute. 3 The University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Houston, Tex. 77030. 4 Address reprint requests to Dr. Strong at her present address: Section of Medical Genetics, Department of Biology, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Tex. 77030. 5 Department of Biomathematics, The University of Texas System Cancer Center. 6 Department of Pathology, The University of Texas System Cancer Center. 7 Department of Pediatrics, The University of Texas System Cancer Center. • We thank Dr. Melvin Samuels, Department of Medicine, The University of Texas System Cancer Center, for permission to report his cases; Dr. H. I. Libshitz, Department of Diagnostic Radiology, for review of X-rays; Dr. R. C. Chan, Department of Radiotherapy, for follow-up information; Ms. Marilyn Stovall, Department of Physics, for review of radiophysical data; and Ms. Jacqueline Hecht and Ms. Renee Shapiro for technical assistance.",
year = "1979",
month = jun,
doi = "10.1093/jnci/62.6.1401",
language = "English (US)",
volume = "62",
pages = "1401--1406",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "6",
}