Abstract
Roles of RNA on transcriptional and post-transcriptional regulations have raised more attention since the new era of genomics. One of the secondary structures of RNA, the RNA G-quadruplex structure, is demonstrated a relatively stable existence in human tumor cells, virus, or other species relating to diseases. G-quadruplexes are special secondary structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. The G-quadruplexes formed in RNA are involved in many biological process including telomere elongation, transcription regulate, pre-mRNA splicing and translation. In this review, we will give a brief introduction to the structures of RNA G-quadruplexes, the biological roles and the potential to be as drug targets.
Original language | English (US) |
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Pages (from-to) | 1947-1956 |
Number of pages | 10 |
Journal | Current Topics in Medicinal Chemistry |
Volume | 15 |
Issue number | 19 |
DOIs | |
State | Published - Jul 1 2015 |
Externally published | Yes |
Keywords
- Biological function
- DNA
- Drug targets
- G-quadruplex
- RNA
ASJC Scopus subject areas
- Drug Discovery