Abstract
Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release.
Original language | English (US) |
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Pages (from-to) | 59-67 |
Number of pages | 9 |
Journal | Nature Reviews Cancer |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2011 |
ASJC Scopus subject areas
- Oncology
- Cancer Research