RNAi in Cancer Therapy

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter discusses the therapeutic opportunities for ncRNA, approaches to overcoming anatomic and physiologic barriers to siRNA delivery, and recent advances in the design of delivery strategies for siRNA, with emphasis on in vivo delivery and intracellular trafficking of therapeutic RNA in cancer therapy.

Original languageEnglish (US)
Title of host publicationAdvanced Delivery and Therapeutic Applications of RNAi
PublisherJohn Wiley and Sons
Number of pages37
ISBN (Print)9781119976868
StatePublished - Apr 26 2013



  • Anatomic and physiologic barriers
  • Cancer
  • Intracellular delivery
  • Intravascular degradation
  • MiRNA
  • Noncoding RNAs
  • Off-target effects

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Rodriguez-Aguayo, C., Chavez-Reyes, A., Lopez-Berestein, G., & Sood, A. K. (2013). RNAi in Cancer Therapy. In Advanced Delivery and Therapeutic Applications of RNAi (pp. 271-307). John Wiley and Sons. https://doi.org/10.1002/9781118610749.ch13