Abstract
The rat neu oncogene encodes a dominant transforming oncogene. The mouse wild-type p53 suppresses the transforming activity of the neu oncogene while different p53 mutants demonstrate varying ability to repress neu-induced transformation. Suppression of neu-transforming activity is due to inhibition of transcription. Deletion analysis of the rat neu promoter shows that p53 represses the basal promoter activity of neu. Therefore, rodent p53 suppresses the transforming potential of neu by inhibiting transcription from the basal promoter of neu.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1087-1092 |
| Number of pages | 6 |
| Journal | International journal of oncology |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1995 |
Keywords
- Mouse p53
- Neu oncogene
- Rat neu promoter
- Transforming activity
ASJC Scopus subject areas
- Oncology
- Cancer Research