TY - JOUR
T1 - Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma
AU - Lin, Richard J.
AU - Behera, Madhusmita
AU - Diefenbach, Catherine S.
AU - Flowers, Christopher R.
N1 - Publisher Copyright:
© 2017 by The American Society of Hematology.
PY - 2017/11/16
Y1 - 2017/11/16
N2 - Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.
AB - Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.
UR - http://www.scopus.com/inward/record.url?scp=85034022033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034022033&partnerID=8YFLogxK
U2 - 10.1182/blood-2017-05-736975
DO - 10.1182/blood-2017-05-736975
M3 - Review article
C2 - 28814386
AN - SCOPUS:85034022033
SN - 0006-4971
VL - 130
SP - 2180
EP - 2185
JO - Blood
JF - Blood
IS - 20
ER -