Role of cancer stem cells in brain tumors

Ya Huey Chen; Mien Chie Hung; Woei Cherng Shyu

doi:10.1016/j.biomed.2012.06.001

Role of cancer stem cells in brain tumors

Ya Huey Chen, Mien Chie Hung, Woei Cherng Shyu

Molecular & Cellular Oncology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Cancer stem cells contribute to tumor progression, resulting in their capacity to persistently self-renew and propagate tumors. Recent evidence suggests that brain cancer stem cells (BCSCs) are critical for tumor vascular development and therapeutic resistance. Here, we outline the crucial molecular mechanisms and interacting niches involved in BCSCs, which uncovering multiple potential targets for malignant brain tumors and may provide clues for developing novel antibrain tumor treatments.

Original language	English (US)
Pages (from-to)	84-91
Number of pages	8
Journal	BioMedicine (Netherlands)
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.biomed.2012.06.001
State	Published - Sep 2012

Keywords

Brain cancer stem cells
CD133
Glioblastoma
Medulloblastomas
Perivascular niche
Targeting therapies

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.biomed.2012.06.001

Cite this

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title = "Role of cancer stem cells in brain tumors",

abstract = "Cancer stem cells contribute to tumor progression, resulting in their capacity to persistently self-renew and propagate tumors. Recent evidence suggests that brain cancer stem cells (BCSCs) are critical for tumor vascular development and therapeutic resistance. Here, we outline the crucial molecular mechanisms and interacting niches involved in BCSCs, which uncovering multiple potential targets for malignant brain tumors and may provide clues for developing novel antibrain tumor treatments.",

keywords = "Brain cancer stem cells, CD133, Glioblastoma, Medulloblastomas, Perivascular niche, Targeting therapies",

author = "Chen, {Ya Huey} and Hung, {Mien Chie} and Shyu, {Woei Cherng}",

year = "2012",

month = sep,

doi = "10.1016/j.biomed.2012.06.001",

language = "English (US)",

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T1 - Role of cancer stem cells in brain tumors

AU - Chen, Ya Huey

AU - Hung, Mien Chie

AU - Shyu, Woei Cherng

PY - 2012/9

Y1 - 2012/9

N2 - Cancer stem cells contribute to tumor progression, resulting in their capacity to persistently self-renew and propagate tumors. Recent evidence suggests that brain cancer stem cells (BCSCs) are critical for tumor vascular development and therapeutic resistance. Here, we outline the crucial molecular mechanisms and interacting niches involved in BCSCs, which uncovering multiple potential targets for malignant brain tumors and may provide clues for developing novel antibrain tumor treatments.

AB - Cancer stem cells contribute to tumor progression, resulting in their capacity to persistently self-renew and propagate tumors. Recent evidence suggests that brain cancer stem cells (BCSCs) are critical for tumor vascular development and therapeutic resistance. Here, we outline the crucial molecular mechanisms and interacting niches involved in BCSCs, which uncovering multiple potential targets for malignant brain tumors and may provide clues for developing novel antibrain tumor treatments.

KW - Brain cancer stem cells

KW - CD133

KW - Glioblastoma

KW - Medulloblastomas

KW - Perivascular niche

KW - Targeting therapies

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DO - 10.1016/j.biomed.2012.06.001

M3 - Review article

AN - SCOPUS:84866489660

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EP - 91

JO - BioMedicine (Netherlands)

JF - BioMedicine (Netherlands)

IS - 3

ER -

Role of cancer stem cells in brain tumors

Abstract

Keywords

ASJC Scopus subject areas

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