Abstract
Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.
Original language | English (US) |
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Pages (from-to) | 281-285 |
Number of pages | 5 |
Journal | Trends in Pharmacological Sciences |
Volume | 10 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1989 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology