Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Hiroto Hatakeyama; Sherry Y. Wu; Yasmin A. Lyons; Sunila Pradeep; Wanqin Wang; Qian Huang; Karem A. Court; Tao Liu; Song Nie; Cristian Rodriguez-Aguayo; Fangrong Shen; Yan Huang; Takeshi Hisamatsu; Takashi Mitamura; Nicholas Jennings; Jeajun Shim; Piotr L. Dorniak; Lingegowda S. Mangala; Marco Petrillo; Vladislav A. Petyuk; Athena A. Schepmoes; Anil K. Shukla; Madeline Torres-Lugo; Ju Seog Lee; Karin D. Rodland; Anna Fagotti; Gabriel Lopez-Berestein; Chun Li; Anil K. Sood

doi:10.1016/j.celrep.2016.10.020

Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Hiroto Hatakeyama, Sherry Y. Wu, Yasmin A. Lyons, Sunila Pradeep, Wanqin Wang, Qian Huang, Karem A. Court, Tao Liu, Song Nie, Cristian Rodriguez-Aguayo, Fangrong Shen, Yan Huang, Takeshi Hisamatsu, Takashi Mitamura, Nicholas Jennings, Jeajun Shim, Piotr L. Dorniak, Lingegowda S. Mangala, Marco Petrillo, Vladislav A. PetyukAthena A. Schepmoes, Anil K. Shukla, Madeline Torres-Lugo, Ju Seog Lee, Karin D. Rodland, Anna Fagotti, Gabriel Lopez-Berestein, Chun Li, Anil K. Sood

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

Original language	English (US)
Pages (from-to)	1621-1631
Number of pages	11
Journal	Cell Reports
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2016.10.020
State	Published - Nov 1 2016

Keywords

CTGF
DOPC-liposome
copper sulfide nanoparticle
hyperthermia
ovarian cancer
thermosensitivity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

MD Anderson CCSG core facilities

Advanced Technology Genomics Core
Flow Cytometry and Cellular Imaging Facility
High Resolution Electron Microscopy Facility
Tissue Biospecimen and Pathology Resource
Cytogenetics and Cell Authentication Core

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10.1016/j.celrep.2016.10.020

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Hatakeyama, H., Wu, S. Y., Lyons, Y. A., Pradeep, S., Wang, W., Huang, Q., Court, K. A., Liu, T., Nie, S., Rodriguez-Aguayo, C., Shen, F., Huang, Y., Hisamatsu, T., Mitamura, T., Jennings, N., Shim, J., Dorniak, P. L., Mangala, L. S., Petrillo, M., ... Sood, A. K. (2016). Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers. Cell Reports, 17(6), 1621-1631. https://doi.org/10.1016/j.celrep.2016.10.020

Hatakeyama, H, Wu, SY, Lyons, YA, Pradeep, S, Wang, W, Huang, Q, Court, KA, Liu, T, Nie, S, Rodriguez-Aguayo, C, Shen, F, Huang, Y, Hisamatsu, T, Mitamura, T, Jennings, N, Shim, J, Dorniak, PL, Mangala, LS, Petrillo, M, Petyuk, VA, Schepmoes, AA, Shukla, AK, Torres-Lugo, M, Lee, JS, Rodland, KD, Fagotti, A, Lopez-Berestein, G , Li, C & Sood, AK 2016, 'Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers', Cell Reports, vol. 17, no. 6, pp. 1621-1631. https://doi.org/10.1016/j.celrep.2016.10.020

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title = "Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers",

abstract = "Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.",

keywords = "CTGF, DOPC-liposome, copper sulfide nanoparticle, hyperthermia, ovarian cancer, thermosensitivity",

author = "Hiroto Hatakeyama and Wu, {Sherry Y.} and Lyons, {Yasmin A.} and Sunila Pradeep and Wanqin Wang and Qian Huang and Court, {Karem A.} and Tao Liu and Song Nie and Cristian Rodriguez-Aguayo and Fangrong Shen and Yan Huang and Takeshi Hisamatsu and Takashi Mitamura and Nicholas Jennings and Jeajun Shim and Dorniak, {Piotr L.} and Mangala, {Lingegowda S.} and Marco Petrillo and Petyuk, {Vladislav A.} and Schepmoes, {Athena A.} and Shukla, {Anil K.} and Madeline Torres-Lugo and Lee, {Ju Seog} and Rodland, {Karin D.} and Anna Fagotti and Gabriel Lopez-Berestein and Chun Li and Sood, {Anil K.}",

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AU - Hatakeyama, Hiroto

AU - Wu, Sherry Y.

AU - Lyons, Yasmin A.

AU - Pradeep, Sunila

AU - Wang, Wanqin

AU - Huang, Qian

AU - Court, Karem A.

AU - Liu, Tao

AU - Nie, Song

AU - Rodriguez-Aguayo, Cristian

AU - Shen, Fangrong

AU - Huang, Yan

AU - Hisamatsu, Takeshi

AU - Mitamura, Takashi

AU - Jennings, Nicholas

AU - Shim, Jeajun

AU - Dorniak, Piotr L.

AU - Mangala, Lingegowda S.

AU - Petrillo, Marco

AU - Petyuk, Vladislav A.

AU - Schepmoes, Athena A.

AU - Shukla, Anil K.

AU - Torres-Lugo, Madeline

AU - Lee, Ju Seog

AU - Rodland, Karin D.

AU - Fagotti, Anna

AU - Lopez-Berestein, Gabriel

AU - Li, Chun

AU - Sood, Anil K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

AB - Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

KW - CTGF

KW - DOPC-liposome

KW - copper sulfide nanoparticle

KW - hyperthermia

KW - ovarian cancer

KW - thermosensitivity

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Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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