Role of Histone Modifications in Chronic Pain Development

Jixiang Zhang; Hui Lin Pan

doi:10.1016/B978-0-12-814070-3.00004-1

Role of Histone Modifications in Chronic Pain Development

Jixiang Zhang, Hui Lin Pan

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

This chapter focuses on the role of histone modifications in chronic pain development. It starts by introducing epigenetic processes, particularly histone modifications, and then chronic pain, especially nerve injury-induced neuropathic pain. It then reviews recent studies on the role of histone modifications in regulating gene expression in chronic pain, including G9a-mediated H3K9me2, EZH2-mediated H3K27me3, and HDAC-mediated histone acetylation. Lastly, it discusses the possible involvement of histone variant turnover in chronic pain development and the potential interaction/overlap of G9a, HDAC, and REST in pain-related gene regulation. Current challenges and prospects for future studies on the epigenetic basis of chronic pain are also discussed.

Original language	English (US)
Title of host publication	Epigenetics of Chronic Pain
Publisher	Elsevier
Pages	85-98
Number of pages	14
ISBN (Electronic)	9780128140703
DOIs	https://doi.org/10.1016/B978-0-12-814070-3.00004-1
State	Published - Jan 1 2018

Keywords

Dorsal root ganglion
Epigenetics
G9a
Histone modifications
Neuronal plasticity
Neuropathic pain

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-814070-3.00004-1

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abstract = "This chapter focuses on the role of histone modifications in chronic pain development. It starts by introducing epigenetic processes, particularly histone modifications, and then chronic pain, especially nerve injury-induced neuropathic pain. It then reviews recent studies on the role of histone modifications in regulating gene expression in chronic pain, including G9a-mediated H3K9me2, EZH2-mediated H3K27me3, and HDAC-mediated histone acetylation. Lastly, it discusses the possible involvement of histone variant turnover in chronic pain development and the potential interaction/overlap of G9a, HDAC, and REST in pain-related gene regulation. Current challenges and prospects for future studies on the epigenetic basis of chronic pain are also discussed.",

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AB - This chapter focuses on the role of histone modifications in chronic pain development. It starts by introducing epigenetic processes, particularly histone modifications, and then chronic pain, especially nerve injury-induced neuropathic pain. It then reviews recent studies on the role of histone modifications in regulating gene expression in chronic pain, including G9a-mediated H3K9me2, EZH2-mediated H3K27me3, and HDAC-mediated histone acetylation. Lastly, it discusses the possible involvement of histone variant turnover in chronic pain development and the potential interaction/overlap of G9a, HDAC, and REST in pain-related gene regulation. Current challenges and prospects for future studies on the epigenetic basis of chronic pain are also discussed.

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KW - Histone modifications

KW - Neuronal plasticity

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Role of Histone Modifications in Chronic Pain Development

Abstract

Keywords

ASJC Scopus subject areas

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