Role of IL12 family in regulation of antitumor immune response

Denada Dibra; Shulin Li

doi:10.1007/978-1-4419-0170-5_1

Role of IL12 family in regulation of antitumor immune response

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The efficacy of immune therapy is partially dependent upon the tumor microenvironment. This microenvironment could either promote or demote tumor growth. Cytokines, which are secreted either by tumor, immune, or stromal cells, are key players that govern the outcome of this microenvironment. One such cytokine family is interleukin (IL)12 and the members of this family include IL12, IL27, IL23, and IL35. In this review, the expression and function of these family members and the cognate receptors in tumor microenvironment and other tissues are summarized and discussed. Our review indicates that, although these heterodimeric cytokines share subunits p35, p40, p19, EBI3, and p28 among these family members, each of them have distinct function. The same gene may also play different function when the expression is localized in different tissues.

Original language	English (US)
Title of host publication	Targeted Cancer Immune Therapy
Publisher	Springer New York
Pages	3-18
Number of pages	16
ISBN (Print)	9781441901699
DOIs	https://doi.org/10.1007/978-1-4419-0170-5_1
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4419-0170-5_1

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abstract = "The efficacy of immune therapy is partially dependent upon the tumor microenvironment. This microenvironment could either promote or demote tumor growth. Cytokines, which are secreted either by tumor, immune, or stromal cells, are key players that govern the outcome of this microenvironment. One such cytokine family is interleukin (IL)12 and the members of this family include IL12, IL27, IL23, and IL35. In this review, the expression and function of these family members and the cognate receptors in tumor microenvironment and other tissues are summarized and discussed. Our review indicates that, although these heterodimeric cytokines share subunits p35, p40, p19, EBI3, and p28 among these family members, each of them have distinct function. The same gene may also play different function when the expression is localized in different tissues.",

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AB - The efficacy of immune therapy is partially dependent upon the tumor microenvironment. This microenvironment could either promote or demote tumor growth. Cytokines, which are secreted either by tumor, immune, or stromal cells, are key players that govern the outcome of this microenvironment. One such cytokine family is interleukin (IL)12 and the members of this family include IL12, IL27, IL23, and IL35. In this review, the expression and function of these family members and the cognate receptors in tumor microenvironment and other tissues are summarized and discussed. Our review indicates that, although these heterodimeric cytokines share subunits p35, p40, p19, EBI3, and p28 among these family members, each of them have distinct function. The same gene may also play different function when the expression is localized in different tissues.

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Role of IL12 family in regulation of antitumor immune response

Abstract

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