TY - JOUR
T1 - Role of metabolic genes in blood arsenic concentrations of Jamaican children with and without autism spectrum disorder
AU - Rahbar, Mohammad H.
AU - Samms-Vaughan, Maureen
AU - Ma, Jianzhong
AU - Bressler, Jan
AU - Loveland, Katherine A.
AU - Ardjomand-Hessabi, Manouchehr
AU - Dickerson, Aisha S.
AU - Grove, Megan L.
AU - Shakespeare-Pellington, Sydonnie
AU - Beecher, Compton
AU - McLaughlin, Wayne
AU - Boerwinkle, Eric
PY - 2014/8/6
Y1 - 2014/8/6
N2 - Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1:1 age- and sex-matched typically developing (TD) controls (age 2-8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 μg/L vs. 2.69 μg/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.
AB - Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1:1 age- and sex-matched typically developing (TD) controls (age 2-8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 μg/L vs. 2.69 μg/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.
KW - Arsenic
KW - Autism spectrum disorder (ASD)
KW - Detoxification
KW - Glutathione S-transferase (GST) genes
KW - Interactions
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U2 - 10.3390/ijerph110807874
DO - 10.3390/ijerph110807874
M3 - Article
C2 - 25101770
AN - SCOPUS:84905653375
SN - 1661-7827
VL - 11
SP - 7874
EP - 7895
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 8
ER -