TY - JOUR
T1 - Role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance
AU - Khan, Sabbir
AU - Mittal, Sandeep
AU - McGee, Kain
AU - Alfaro-Munoz, Kristin D.
AU - Majd, Nazanin
AU - Balasubramaniyan, Veerakumar
AU - de Groot, John F.
N1 - Funding Information:
Funding: This research was supported, in part, by the National Brain Tumor Society (NBTS) and NBTS Sharpe Award.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/3
Y1 - 2020/3
N2 - Recent efforts in brain tumor research have been directed towards the modulation of the immune system for therapeutic interventions. Several human cancers, including gliomas, are infiltrated with immune cell types—including neutrophils and myeloid-derived suppressor cells—that contribute to tumor progression, invasiveness, and treatment resistance. The role of tumor-associated neutrophils and myeloid-derived suppressor cells in cancer biology remains elusive, as these cells can exert a multitude of pro-tumor and antitumor effects. In this review, we provide the current understanding and novel insights on the role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance, as well as the mechanisms of pleiotropic behaviors in these cells during disease progression, with an emphasis on possible strategies to reprogram these cells towards their antitumor actions.
AB - Recent efforts in brain tumor research have been directed towards the modulation of the immune system for therapeutic interventions. Several human cancers, including gliomas, are infiltrated with immune cell types—including neutrophils and myeloid-derived suppressor cells—that contribute to tumor progression, invasiveness, and treatment resistance. The role of tumor-associated neutrophils and myeloid-derived suppressor cells in cancer biology remains elusive, as these cells can exert a multitude of pro-tumor and antitumor effects. In this review, we provide the current understanding and novel insights on the role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance, as well as the mechanisms of pleiotropic behaviors in these cells during disease progression, with an emphasis on possible strategies to reprogram these cells towards their antitumor actions.
KW - Glioma progression
KW - Myeloid-derived suppressor cells
KW - Neutrophils
KW - Treatment resistance
KW - Tumor-associated neutrophils
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U2 - 10.3390/ijms21061954
DO - 10.3390/ijms21061954
M3 - Review article
C2 - 32182988
AN - SCOPUS:85081897929
SN - 1661-6596
VL - 21
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 6
M1 - 1954
ER -