Role of the Human Leukocyte Antigen System in Hematopoietic Stem Cell Transplantation

Kai Cao; Jun Zou; Marcelo A. Fernández-Viña

doi:10.1016/B978-0-323-79833-4.00002-4

Role of the Human Leukocyte Antigen System in Hematopoietic Stem Cell Transplantation

Kai Cao, Jun Zou, Marcelo A. Fernández-Viña

Laboratory Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Human leukocyte antigen (HLA) testing plays an important role in hematopoietic stem cell transplantation (HCT). This chapter provides an overview of an HLA laboratory in support of HCT highlighting several emerging areas with current practice. The chapter mainly covers the topics on HLA genes; HLA nomenclature; HLA testing including HLA typing, HLA antibody identification, and natural killer cell immunoglobulin receptor gene typing. In addition, this chapter briefly reviewed HLA disparity in donor selection; donor-specific anti-HLA antibody identification and desensitization strategies; and HLA molecular mismatch algorithms in the assessment of HLA alloimmune risk.

Original language	English (US)
Title of host publication	Manual of Hematopoietic Cell Transplantation and Cellular Therapies
Publisher	Elsevier
Pages	17-25
Number of pages	9
ISBN (Electronic)	9780323798334
ISBN (Print)	9780323798341
DOIs	https://doi.org/10.1016/B978-0-323-79833-4.00002-4
State	Published - Jan 1 2023

Keywords

Anti-HLA antibody identification
Anti-HLA donor-specific antibody (DSA)
Hematopoietic stem cell transplant (HCT)
HLA matching and donor selection
HLA typing methods
Human leukocyte antigen (HLA)

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-79833-4.00002-4

Cite this

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abstract = "Human leukocyte antigen (HLA) testing plays an important role in hematopoietic stem cell transplantation (HCT). This chapter provides an overview of an HLA laboratory in support of HCT highlighting several emerging areas with current practice. The chapter mainly covers the topics on HLA genes; HLA nomenclature; HLA testing including HLA typing, HLA antibody identification, and natural killer cell immunoglobulin receptor gene typing. In addition, this chapter briefly reviewed HLA disparity in donor selection; donor-specific anti-HLA antibody identification and desensitization strategies; and HLA molecular mismatch algorithms in the assessment of HLA alloimmune risk.",

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AB - Human leukocyte antigen (HLA) testing plays an important role in hematopoietic stem cell transplantation (HCT). This chapter provides an overview of an HLA laboratory in support of HCT highlighting several emerging areas with current practice. The chapter mainly covers the topics on HLA genes; HLA nomenclature; HLA testing including HLA typing, HLA antibody identification, and natural killer cell immunoglobulin receptor gene typing. In addition, this chapter briefly reviewed HLA disparity in donor selection; donor-specific anti-HLA antibody identification and desensitization strategies; and HLA molecular mismatch algorithms in the assessment of HLA alloimmune risk.

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Role of the Human Leukocyte Antigen System in Hematopoietic Stem Cell Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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