Roles of negative and positive growth regulators in nasopharyngeal carcinoma

Mong Hong Lee, Huiling Yang, Ruiying Zhao, Sai Ching J. Yeung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell cycle dysregulation plays an important role of tumorigenesis. Naso\-pharyngeal carcinoma (NPC) cells are affected by numerous cell cycle regulators either act as negative or positive regulators, and their aberrations result in proliferative advantage for NPC cancer cells. Many cell cycle regulators are deregulated in NPC providing the growth advantage. The molecular regulators associated with cell cycle growth are of particular interest because they are potential therapeutic targets for NPC. We focus on recent advances in regulators of the cell cycle and discuss their potential use as therapeutic targets for NPC.

Original languageEnglish (US)
Title of host publicationApoptosis in Carcinogenesis and Chemotherapy
Subtitle of host publicationApoptosis in Cancer
PublisherSpringer Netherlands
Pages273-294
Number of pages22
ISBN (Electronic)9781402095979
ISBN (Print)9781402095962
DOIs
StatePublished - Jan 1 2009

Fingerprint

Cell Cycle
Carcinoma
Growth
Pharyngeal Neoplasms
Therapeutic Uses
Carcinogenesis
Nasopharyngeal carcinoma
Therapeutics

Keywords

  • Cell cycle
  • Nasopharyngeal carcinoma
  • Signaling transduction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lee, M. H., Yang, H., Zhao, R., & Yeung, S. C. J. (2009). Roles of negative and positive growth regulators in nasopharyngeal carcinoma. In Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in Cancer (pp. 273-294). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9597-9-12

Roles of negative and positive growth regulators in nasopharyngeal carcinoma. / Lee, Mong Hong; Yang, Huiling; Zhao, Ruiying; Yeung, Sai Ching J.

Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in Cancer. Springer Netherlands, 2009. p. 273-294.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lee, MH, Yang, H, Zhao, R & Yeung, SCJ 2009, Roles of negative and positive growth regulators in nasopharyngeal carcinoma. in Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in Cancer. Springer Netherlands, pp. 273-294. https://doi.org/10.1007/978-1-4020-9597-9-12
Lee MH, Yang H, Zhao R, Yeung SCJ. Roles of negative and positive growth regulators in nasopharyngeal carcinoma. In Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in Cancer. Springer Netherlands. 2009. p. 273-294 https://doi.org/10.1007/978-1-4020-9597-9-12
Lee, Mong Hong ; Yang, Huiling ; Zhao, Ruiying ; Yeung, Sai Ching J. / Roles of negative and positive growth regulators in nasopharyngeal carcinoma. Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in Cancer. Springer Netherlands, 2009. pp. 273-294
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