Roles of negative and positive growth regulators in nasopharyngeal carcinoma

Cell cycle dysregulation plays an important role of tumorigenesis. Naso\-pharyngeal carcinoma (NPC) cells are affected by numerous cell cycle regulators either act as negative or positive regulators, and their aberrations result in proliferative advantage for NPC cancer cells. Many cell cycle regulators are deregulated in NPC providing the growth advantage. The molecular regulators associated with cell cycle growth are of particular interest because they are potential therapeutic targets for NPC. We focus on recent advances in regulators of the cell cycle and discuss their potential use as therapeutic targets for NPC.