Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development

Rachel D. Mullen; Stephanie C. Colvin; Chad S. Hunter; Jesse J. Savage; Emily C. Walvoord; Amrit P.S. Bhangoo; Svetlana Ten; Johannes Weigel; Roland W. Pfäffle; Simon J. Rhodes

doi:10.1016/j.mce.2006.12.019

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development

Rachel D. Mullen, Stephanie C. Colvin, Chad S. Hunter, Jesse J. Savage, Emily C. Walvoord, Amrit P.S. Bhangoo, Svetlana Ten, Johannes Weigel, Roland W. Pfäffle, Simon J. Rhodes

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

Original language	English (US)
Pages (from-to)	190-195
Number of pages	6
Journal	Molecular and cellular endocrinology
Volume	265-266
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/j.mce.2006.12.019
State	Published - Feb 2007
Externally published	Yes

Keywords

Anterior pituitary
Growth
Hormone
Transcription

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2006.12.019

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title = "Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development",

abstract = "The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.",

keywords = "Anterior pituitary, Growth, Hormone, Transcription",

author = "Mullen, {Rachel D.} and Colvin, {Stephanie C.} and Hunter, {Chad S.} and Savage, {Jesse J.} and Walvoord, {Emily C.} and Bhangoo, {Amrit P.S.} and Svetlana Ten and Johannes Weigel and Pf{\"a}ffle, {Roland W.} and Rhodes, {Simon J.}",

note = "Funding Information: The authors apologize to any colleagues whose work was not mentioned due to space constraints. SJR is supported by grants from the National Institutes of Health (HD42024) and the National Science Foundation (IBN 0131702).",

year = "2007",

month = feb,

doi = "10.1016/j.mce.2006.12.019",

language = "English (US)",

volume = "265-266",

pages = "190--195",

journal = "Molecular and cellular endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

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T1 - Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development

AU - Mullen, Rachel D.

AU - Colvin, Stephanie C.

AU - Hunter, Chad S.

AU - Savage, Jesse J.

AU - Walvoord, Emily C.

AU - Bhangoo, Amrit P.S.

AU - Ten, Svetlana

AU - Weigel, Johannes

AU - Pfäffle, Roland W.

AU - Rhodes, Simon J.

N1 - Funding Information: The authors apologize to any colleagues whose work was not mentioned due to space constraints. SJR is supported by grants from the National Institutes of Health (HD42024) and the National Science Foundation (IBN 0131702).

PY - 2007/2

Y1 - 2007/2

N2 - The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

AB - The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.

KW - Anterior pituitary

KW - Growth

KW - Hormone

KW - Transcription

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AN - SCOPUS:33847042675

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EP - 195

JO - Molecular and cellular endocrinology

JF - Molecular and cellular endocrinology

IS - SUPPL.

ER -

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development

Abstract

Keywords

ASJC Scopus subject areas

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