RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer

Chengzhen Ren; Likun Li; Guang Yang; Terry L. Timme; Alexei Goltsov; Chenghui Ren; Xiaorong Ji; Josephine Addai; Hongbin Luo; Michael M. Ittmann; Timothy C. Thompson

doi:10.1158/0008-5472.CAN-03-2592

RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer

Chengzhen Ren, Likun Li, Guang Yang, Terry L. Timme, Alexei Goltsov, Chenghui Ren, Xiaorong Ji, Josephine Addai, Hongbin Luo, Michael M. Ittmann, Timothy C. Thompson

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.

Original language	English (US)
Pages (from-to)	969-976
Number of pages	8
Journal	Cancer Research
Volume	64
Issue number	3
DOIs	https://doi.org/10.1158/0008-5472.CAN-03-2592
State	Published - Feb 1 2004

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer",

abstract = "We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.",

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T1 - RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer

AU - Ren, Chengzhen

AU - Li, Likun

AU - Yang, Guang

AU - Timme, Terry L.

AU - Goltsov, Alexei

AU - Ren, Chenghui

AU - Ji, Xiaorong

AU - Addai, Josephine

AU - Luo, Hongbin

AU - Ittmann, Michael M.

AU - Thompson, Timothy C.

PY - 2004/2/1

Y1 - 2004/2/1

N2 - We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.

AB - We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.

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RTVP-1, a Tumor Suppressor Inactivated by Methylation in Prostate Cancer

Abstract

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