Safe Opioid Use: Management of Opioid-Related Adverse Effects and Aberrant Behaviors

Joseph Arthur; David Hui

doi:10.1016/j.hoc.2018.01.003

Safe Opioid Use: Management of Opioid-Related Adverse Effects and Aberrant Behaviors

Joseph Arthur, David Hui

Palliative, Rehabilitation, and Integrative Medicine

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. This article provides a synopsis on the management of various opioid-related adverse effects and strategies to minimize aberrant opioid use in patients who have cancer. Many adverse effects can be effectively managed. Some patients on chronic opioid therapy may demonstrate aberrant behaviors suggestive of opioid misuse or diversion. Through intensive education, longitudinal monitoring, early identification, and timely management, clinicians can optimize the risk to benefit ratio to support safe opioid use.

Original language	English (US)
Pages (from-to)	387-403
Number of pages	17
Journal	Hematology/Oncology Clinics of North America
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.hoc.2018.01.003
State	Published - Jun 2018

Keywords

Aberrant behavior
Adverse effects
Cancer
Constipation
Nausea
Opioid
Sedation
Tolerance

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2018.01.003

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title = "Safe Opioid Use: Management of Opioid-Related Adverse Effects and Aberrant Behaviors",

abstract = "Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. This article provides a synopsis on the management of various opioid-related adverse effects and strategies to minimize aberrant opioid use in patients who have cancer. Many adverse effects can be effectively managed. Some patients on chronic opioid therapy may demonstrate aberrant behaviors suggestive of opioid misuse or diversion. Through intensive education, longitudinal monitoring, early identification, and timely management, clinicians can optimize the risk to benefit ratio to support safe opioid use.",

keywords = "Aberrant behavior, Adverse effects, Cancer, Constipation, Nausea, Opioid, Sedation, Tolerance",

author = "Joseph Arthur and David Hui",

note = "Funding Information: Financial and Competing Interest Disclosure: No relevant conflict of interest. D. Hui is supported in part by National Institutes of Health grants (1R01CA214960-01A1, R21NR016736), an American Cancer Society Mentored Research Scholar grant in Applied and Clinical Research (MRSG-14-1418-01-CCE), and the Andrew Sabin Family Fellowship Award. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

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AU - Arthur, Joseph

AU - Hui, David

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PY - 2018/6

Y1 - 2018/6

N2 - Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. This article provides a synopsis on the management of various opioid-related adverse effects and strategies to minimize aberrant opioid use in patients who have cancer. Many adverse effects can be effectively managed. Some patients on chronic opioid therapy may demonstrate aberrant behaviors suggestive of opioid misuse or diversion. Through intensive education, longitudinal monitoring, early identification, and timely management, clinicians can optimize the risk to benefit ratio to support safe opioid use.

AB - Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. This article provides a synopsis on the management of various opioid-related adverse effects and strategies to minimize aberrant opioid use in patients who have cancer. Many adverse effects can be effectively managed. Some patients on chronic opioid therapy may demonstrate aberrant behaviors suggestive of opioid misuse or diversion. Through intensive education, longitudinal monitoring, early identification, and timely management, clinicians can optimize the risk to benefit ratio to support safe opioid use.

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KW - Adverse effects

KW - Cancer

KW - Constipation

KW - Nausea

KW - Opioid

KW - Sedation

KW - Tolerance

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Safe Opioid Use: Management of Opioid-Related Adverse Effects and Aberrant Behaviors

Abstract

Keywords

ASJC Scopus subject areas

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