TY - JOUR
T1 - Salivary gland cancers
T2 - Biology and molecular targets for therapy
AU - Bell, Diana
AU - Hanna, E. Y.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/4
Y1 - 2012/4
N2 - Salivary gland carcinomas are a heterogeneous group of tumors with different biologic behavior. Given the lack of large randomized studies, there is no standard treatment for advanced and/or metastatic salivary gland tumors, and systemic therapy is empirically based. Tumorspecific recurrent chromosomal translocations and fusion oncogenes in aggressive head and neck malignancies have diagnostic, therapeutic, and prognostic implications. Pathognomonic fusion transcripts have been identified in subsets of mucoepidermoid carcinoma and adenoid cystic carcinoma. These translocations target 1) transcription factors involved in growth factor signaling and cell cycle regulation, 2) transcriptional co-activators, and 3) tyrosine kinase receptors. Prioritizing studies with a translational component to advance the molecular understanding of these cancers and moleculartargeted therapy clinical trials is critical.
AB - Salivary gland carcinomas are a heterogeneous group of tumors with different biologic behavior. Given the lack of large randomized studies, there is no standard treatment for advanced and/or metastatic salivary gland tumors, and systemic therapy is empirically based. Tumorspecific recurrent chromosomal translocations and fusion oncogenes in aggressive head and neck malignancies have diagnostic, therapeutic, and prognostic implications. Pathognomonic fusion transcripts have been identified in subsets of mucoepidermoid carcinoma and adenoid cystic carcinoma. These translocations target 1) transcription factors involved in growth factor signaling and cell cycle regulation, 2) transcriptional co-activators, and 3) tyrosine kinase receptors. Prioritizing studies with a translational component to advance the molecular understanding of these cancers and moleculartargeted therapy clinical trials is critical.
KW - Adenoid cystic carcinoma
KW - Fusion oncogenes
KW - Head and neck cancers
KW - Molecular targeted therapy
KW - Mucoepidermoid carcinoma
KW - Salivary cancers
UR - http://www.scopus.com/inward/record.url?scp=84860852345&partnerID=8YFLogxK
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U2 - 10.1007/s11912-012-0220-5
DO - 10.1007/s11912-012-0220-5
M3 - Article
C2 - 22246609
AN - SCOPUS:84860852345
SN - 1523-3790
VL - 14
SP - 166
EP - 174
JO - Current oncology reports
JF - Current oncology reports
IS - 2
ER -