Salivary neoplasms of the palate: A flow cytometric and clinicopathological analysis

R. Carrillo; J. G. Batsakis; R. Weber; M. A. Luna; A. K. El-Naggar

doi:10.1017/s0022215100124648

Salivary neoplasms of the palate: A flow cytometric and clinicopathological analysis

R. Carrillo, J. G. Batsakis, R. Weber, M. A. Luna, A. K. El-Naggar

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (> 5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.

Original language	English (US)
Pages (from-to)	858-861
Number of pages	4
Journal	Journal of Laryngology and Otology
Volume	107
Issue number	9
DOIs	https://doi.org/10.1017/s0022215100124648
State	Published - 1993

Keywords

Adenocarcinoma, terminal duct
Carcinoma, adenoid cystic
DNA
Flow cytometry
Palate
Salivary gland neoplasms

ASJC Scopus subject areas

Otorhinolaryngology

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title = "Salivary neoplasms of the palate: A flow cytometric and clinicopathological analysis",

abstract = "In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (> 5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.",

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T2 - A flow cytometric and clinicopathological analysis

AU - Carrillo, R.

AU - Batsakis, J. G.

AU - Weber, R.

AU - Luna, M. A.

AU - El-Naggar, A. K.

PY - 1993

Y1 - 1993

N2 - In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (> 5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.

AB - In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (> 5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.

KW - Adenocarcinoma, terminal duct

KW - Carcinoma, adenoid cystic

KW - DNA

KW - Flow cytometry

KW - Palate

KW - Salivary gland neoplasms

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Salivary neoplasms of the palate: A flow cytometric and clinicopathological analysis

Abstract

Keywords

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