Sarcomas

Armen Parsyan; James L. Chen; Raphael Pollock; Sarkis Meterissian

doi:10.1007/978-94-017-9078-9_22

Sarcomas

Armen Parsyan, James L. Chen, Raphael Pollock, Sarkis Meterissian

Surgical Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Sarcomas, as opposed to carcinoma, are rare forms of human cancer comprising less than 1∈% of adult cancers. While represented by a broad range of entities, sarcomas share a common ground that is a mesenchymal origin of the tumors. With the understanding of these various types of sarcomas at the molecular level recently gaining its momentum, the role of translation in the pathobiology of this group of diseases started to uncover, pointing at a common theme: the activation of the mTOR pathway with subsequent derepression of the function of eIF4E via 4E-BPs and the activation of the proproliferative translation program. In this chapter, we, for the first time, summarize the current knowledge regarding translation, its regulation, as well as diagnostic and therapeutic potential in various types of sarcomas.

Original language	English (US)
Title of host publication	Translation and Its Regulation in Cancer Biology and Medicine
Publisher	Springer Netherlands
Pages	453-466
Number of pages	14
ISBN (Electronic)	9789401790789
ISBN (Print)	9401790779, 9789401790772
DOIs	https://doi.org/10.1007/978-94-017-9078-9_22
State	Published - Mar 1 2014

Keywords

Cancer
Cell signaling
Gastrointestinal stromal tumor (GIST)
Protein synthesis
Sarcoma
Targeted therapy
Translation
eIF4E
eIF4E-binding protein (4E-BP)
mTOR pathway

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-94-017-9078-9_22

Cite this

@inbook{1922e6c5b3f246a6b3602b8b196df53e,

title = "Sarcomas",

abstract = "Sarcomas, as opposed to carcinoma, are rare forms of human cancer comprising less than 1∈% of adult cancers. While represented by a broad range of entities, sarcomas share a common ground that is a mesenchymal origin of the tumors. With the understanding of these various types of sarcomas at the molecular level recently gaining its momentum, the role of translation in the pathobiology of this group of diseases started to uncover, pointing at a common theme: the activation of the mTOR pathway with subsequent derepression of the function of eIF4E via 4E-BPs and the activation of the proproliferative translation program. In this chapter, we, for the first time, summarize the current knowledge regarding translation, its regulation, as well as diagnostic and therapeutic potential in various types of sarcomas.",

keywords = "Cancer, Cell signaling, Gastrointestinal stromal tumor (GIST), Protein synthesis, Sarcoma, Targeted therapy, Translation, eIF4E, eIF4E-binding protein (4E-BP), mTOR pathway",

author = "Armen Parsyan and Chen, {James L.} and Raphael Pollock and Sarkis Meterissian",

year = "2014",

month = mar,

day = "1",

doi = "10.1007/978-94-017-9078-9_22",

language = "English (US)",

isbn = "9401790779",

pages = "453--466",

booktitle = "Translation and Its Regulation in Cancer Biology and Medicine",

publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Sarcomas

AU - Parsyan, Armen

AU - Chen, James L.

AU - Pollock, Raphael

AU - Meterissian, Sarkis

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Sarcomas, as opposed to carcinoma, are rare forms of human cancer comprising less than 1∈% of adult cancers. While represented by a broad range of entities, sarcomas share a common ground that is a mesenchymal origin of the tumors. With the understanding of these various types of sarcomas at the molecular level recently gaining its momentum, the role of translation in the pathobiology of this group of diseases started to uncover, pointing at a common theme: the activation of the mTOR pathway with subsequent derepression of the function of eIF4E via 4E-BPs and the activation of the proproliferative translation program. In this chapter, we, for the first time, summarize the current knowledge regarding translation, its regulation, as well as diagnostic and therapeutic potential in various types of sarcomas.

AB - Sarcomas, as opposed to carcinoma, are rare forms of human cancer comprising less than 1∈% of adult cancers. While represented by a broad range of entities, sarcomas share a common ground that is a mesenchymal origin of the tumors. With the understanding of these various types of sarcomas at the molecular level recently gaining its momentum, the role of translation in the pathobiology of this group of diseases started to uncover, pointing at a common theme: the activation of the mTOR pathway with subsequent derepression of the function of eIF4E via 4E-BPs and the activation of the proproliferative translation program. In this chapter, we, for the first time, summarize the current knowledge regarding translation, its regulation, as well as diagnostic and therapeutic potential in various types of sarcomas.

KW - Cancer

KW - Cell signaling

KW - Gastrointestinal stromal tumor (GIST)

KW - Protein synthesis

KW - Sarcoma

KW - Targeted therapy

KW - Translation

KW - eIF4E

KW - eIF4E-binding protein (4E-BP)

KW - mTOR pathway

UR - http://www.scopus.com/inward/record.url?scp=84930918792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930918792&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-9078-9_22

DO - 10.1007/978-94-017-9078-9_22

M3 - Chapter

AN - SCOPUS:84930918792

SN - 9401790779

SN - 9789401790772

SP - 453

EP - 466

BT - Translation and Its Regulation in Cancer Biology and Medicine

PB - Springer Netherlands

ER -

Sarcomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this