TY - GEN
T1 - Schizophrenia genes
T2 - BioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
AU - Sun, Jingchun
AU - Han, Leng
AU - Zhao, Zhongming
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Schizophrenia is a heritable complex disease that involves multiple genes interacting themselves or with environment. Its genetic mechanisms have not been well understood. Currently, studies have revealed hundreds of genes associated with schizophrenia. This provides us an opportunity to explore the molecular characteristics of schizophrenia genes (SCZGenes) using genomics and systems biology approaches. In this study, we selected SCZGenes based on the published association studies and examined their functional features by comparing to the neurodevelopmental genes and control genes. We revealed that SCZGenes have strong correlation with neurodevelopment and other functional term. We further investigated the topological characteristics of SCZGenes in the human protein interaction network. We found that SCZGenes do not tend to encode hub proteins; rather they interact in a modest degree. Finally, we extracted SCZGenes subnetworks, which may be further analyzed with other information.
AB - Schizophrenia is a heritable complex disease that involves multiple genes interacting themselves or with environment. Its genetic mechanisms have not been well understood. Currently, studies have revealed hundreds of genes associated with schizophrenia. This provides us an opportunity to explore the molecular characteristics of schizophrenia genes (SCZGenes) using genomics and systems biology approaches. In this study, we selected SCZGenes based on the published association studies and examined their functional features by comparing to the neurodevelopmental genes and control genes. We revealed that SCZGenes have strong correlation with neurodevelopment and other functional term. We further investigated the topological characteristics of SCZGenes in the human protein interaction network. We found that SCZGenes do not tend to encode hub proteins; rather they interact in a modest degree. Finally, we extracted SCZGenes subnetworks, which may be further analyzed with other information.
UR - http://www.scopus.com/inward/record.url?scp=51549098584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51549098584&partnerID=8YFLogxK
U2 - 10.1109/BMEI.2008.227
DO - 10.1109/BMEI.2008.227
M3 - Conference contribution
AN - SCOPUS:51549098584
SN - 9780769531182
T3 - BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
SP - 437
EP - 441
BT - BioMedical Engineering and Informatics
Y2 - 27 May 2008 through 30 May 2008
ER -