TY - JOUR
T1 - Sclerosing orbital pseudotumor with involvement of the optic nerve
AU - Amin, Hesham M.
AU - Perlman, Jay I.
AU - Close, Troy W.
AU - Collins, Sharon L.
AU - Thomas, Chinnamma
PY - 2008/4
Y1 - 2008/4
N2 - A 34-year-old, African-American woman presented with severe left orbital pain and headaches, associated with gradual, progressive loss of vision. Computerized tomography scanning showed infiltration of the retrobulbar tissue and surrounding soft tissue by a diffuse, ill-defined mass. A biopsy of the mass was diagnosed as inflammatory pseudotumor. Subsequently, the patient received corticosteroids, cytotoxic agents, and radiation therapy without noticeable improvement. She then underwent left orbital exenteration for pain resistant to narcotic analgesia. Histopathologic evaluation of the lesion demonstrated focal polymorphous inflammatory infiltrate in a background of extensive, diffuse sclerotic tissue. The optic nerve, sinus bone, and cartilage were infiltrated by a similar process. The clinical presentation and histo-pathologic criteria established a diagnosis of sclerosing orbital pseudotumor. Such a lesion represents a unique, clinicopathologic variant of inflammatory orbital pseudotumors. The patient is currently asymptomatic without evidence of recurrence one year after the surgery.
AB - A 34-year-old, African-American woman presented with severe left orbital pain and headaches, associated with gradual, progressive loss of vision. Computerized tomography scanning showed infiltration of the retrobulbar tissue and surrounding soft tissue by a diffuse, ill-defined mass. A biopsy of the mass was diagnosed as inflammatory pseudotumor. Subsequently, the patient received corticosteroids, cytotoxic agents, and radiation therapy without noticeable improvement. She then underwent left orbital exenteration for pain resistant to narcotic analgesia. Histopathologic evaluation of the lesion demonstrated focal polymorphous inflammatory infiltrate in a background of extensive, diffuse sclerotic tissue. The optic nerve, sinus bone, and cartilage were infiltrated by a similar process. The clinical presentation and histo-pathologic criteria established a diagnosis of sclerosing orbital pseudotumor. Such a lesion represents a unique, clinicopathologic variant of inflammatory orbital pseudotumors. The patient is currently asymptomatic without evidence of recurrence one year after the surgery.
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M3 - Review article
AN - SCOPUS:43949083366
SN - 1705-4842
VL - 26
SP - 134
EP - 139
JO - Clinical and Surgical Ophthalmology
JF - Clinical and Surgical Ophthalmology
IS - 4
ER -