TY - JOUR
T1 - Screening test results associated with cancer diagnoses in 287 women with cervical squamous cell carcinoma
AU - Li, Zaibo
AU - Austin, R. Marshall
AU - Guo, Ming
AU - Zhao, Chengquan
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/12
Y1 - 2012/12
N2 - Context.-The limitations of newer cervical screening tests are still being studied. Objective.-To investigate those limitations, we conducted a retrospective review of 287 cases of cervical squamous cell carcinoma (SCC). Design.-a search through 5 years of records identified 287 women with cervical SCC diagnoses. Clinical history, histopathology, and liquid-based cytology (ThinPrep) and Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) results were documented. Polymerase chain reaction HPV tests were performed on SCC tissues with prior negative HC2 results. Results.-Of 287 women, 156 (54.4%) had abnormal cytology results, and 75 (26.1%) had abnormal clinical findings triggering tissue diagnoses of SCC. Among 156 patients with abnormal Papanicolaou (Pap) test results, more-seriously abnormal Pap test results were reported in 142 women (91.1%). Among 31 women with Pap and HC2 HPV cotesting within 1 year of SCC diagnoses, 28 (90%) were Pap + /HPV+ , 2 (15.5%) were Pap+ /HPV-, and 1 (3%) was Pap - /HPV-. Two of 3 women with negative HC2 results before SCC diagnosis had abnormal Pap results; 1 had negative Pap reports with questionable lesional cells mimicking atrophy. In all 3 cases of SCC with negative HC2 results, HPV-18 was detected; in 2 cases (66%), HPV- 16 was also detected. Conclusions.-Although abnormal cytology preceded most SCC diagnoses, about one-third of patients were referred for diagnostic testing because of clinical suspicion alone. Among 31 SCC cases with liquid-based cytology and high-risk HPV cotest results less than 1 year before SCC diagnoses, 2 patients (6.5%) had Pap+ /HPV- results, and 1 patient (3.2%) had Pap- /HPV- results. Polymerase chain reaction detected high-risk HPV DNA in tumor tissues of 3 SCC cases with recent HC2- results.
AB - Context.-The limitations of newer cervical screening tests are still being studied. Objective.-To investigate those limitations, we conducted a retrospective review of 287 cases of cervical squamous cell carcinoma (SCC). Design.-a search through 5 years of records identified 287 women with cervical SCC diagnoses. Clinical history, histopathology, and liquid-based cytology (ThinPrep) and Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) results were documented. Polymerase chain reaction HPV tests were performed on SCC tissues with prior negative HC2 results. Results.-Of 287 women, 156 (54.4%) had abnormal cytology results, and 75 (26.1%) had abnormal clinical findings triggering tissue diagnoses of SCC. Among 156 patients with abnormal Papanicolaou (Pap) test results, more-seriously abnormal Pap test results were reported in 142 women (91.1%). Among 31 women with Pap and HC2 HPV cotesting within 1 year of SCC diagnoses, 28 (90%) were Pap + /HPV+ , 2 (15.5%) were Pap+ /HPV-, and 1 (3%) was Pap - /HPV-. Two of 3 women with negative HC2 results before SCC diagnosis had abnormal Pap results; 1 had negative Pap reports with questionable lesional cells mimicking atrophy. In all 3 cases of SCC with negative HC2 results, HPV-18 was detected; in 2 cases (66%), HPV- 16 was also detected. Conclusions.-Although abnormal cytology preceded most SCC diagnoses, about one-third of patients were referred for diagnostic testing because of clinical suspicion alone. Among 31 SCC cases with liquid-based cytology and high-risk HPV cotest results less than 1 year before SCC diagnoses, 2 patients (6.5%) had Pap+ /HPV- results, and 1 patient (3.2%) had Pap- /HPV- results. Polymerase chain reaction detected high-risk HPV DNA in tumor tissues of 3 SCC cases with recent HC2- results.
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U2 - 10.5858/arpa.2011-0609-OA
DO - 10.5858/arpa.2011-0609-OA
M3 - Article
C2 - 22900617
AN - SCOPUS:84869210546
SN - 0003-9985
VL - 136
SP - 1533
EP - 1540
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 12
ER -