TY - JOUR
T1 - Secondary Acute Myelogenous Leukemia in Patients with Retinoblastoma. Is Chemotherapy a Factor?
AU - Gombos, Dan S.
AU - Hungerford, John
AU - Abramson, David H.
AU - Kingston, Judith
AU - Chantada, Guillermo
AU - Dunkel, Ira J.
AU - Antoneli, Celia B.G.
AU - Greenwald, Mark
AU - Haik, Barret G.
AU - Leal, Carlos A.
AU - Medina-Sanson, Aurora
AU - Schefler, Amy C.
AU - Veerakul, Gavivann
AU - Wieland, Regina
AU - Bornfeld, Norbert
AU - Wilson, Mathew W.
AU - Yu, Christopher Bing On
PY - 2007/7
Y1 - 2007/7
N2 - Purpose: To describe a series of patients with secondary acute myelogenous leukemia (sAML) and retinoblastoma (RB). Design: Retrospective observational cases series. Participants: Ocular and pediatric oncologists at referral centers in Europe and the Americas and the RB databases at the National Institutes of Health and the Ophthalmic Oncology Service at Memorial Sloan-Kettering Cancer Center. Methods: Physician survey, retrospective database review, and literature search. Main Outcome Measures: History of RB and development of sAML, management of RB (surgery, radiotherapy, chemotherapy), age at diagnosis of RB and leukemia, French-American-British (FAB) subtype, and current status of patient (alive or dead). Results: Fifteen patients with sAML were identified; 13 occurred in childhood. Mean latent period from RB to AML diagnosis was 9.8 years (median, 42 months). Nine cases were of the M2 or M5 FAB subtypes. Twelve patients (79 %) had received chemotherapy with a topoisomerase II inhibitor, 8 (43%) had received chemotherapy with an epipodophyllotoxin. Ten children died of their leukemia. Conclusions: Acute myelogenous leukemia is a rare secondary malignancy among retinoblastoma patients, many of whom were treated with primary or adjuvant chemotherapy. Additional studies are needed to assess potential risk factors contributing to sAML development in this cohort.
AB - Purpose: To describe a series of patients with secondary acute myelogenous leukemia (sAML) and retinoblastoma (RB). Design: Retrospective observational cases series. Participants: Ocular and pediatric oncologists at referral centers in Europe and the Americas and the RB databases at the National Institutes of Health and the Ophthalmic Oncology Service at Memorial Sloan-Kettering Cancer Center. Methods: Physician survey, retrospective database review, and literature search. Main Outcome Measures: History of RB and development of sAML, management of RB (surgery, radiotherapy, chemotherapy), age at diagnosis of RB and leukemia, French-American-British (FAB) subtype, and current status of patient (alive or dead). Results: Fifteen patients with sAML were identified; 13 occurred in childhood. Mean latent period from RB to AML diagnosis was 9.8 years (median, 42 months). Nine cases were of the M2 or M5 FAB subtypes. Twelve patients (79 %) had received chemotherapy with a topoisomerase II inhibitor, 8 (43%) had received chemotherapy with an epipodophyllotoxin. Ten children died of their leukemia. Conclusions: Acute myelogenous leukemia is a rare secondary malignancy among retinoblastoma patients, many of whom were treated with primary or adjuvant chemotherapy. Additional studies are needed to assess potential risk factors contributing to sAML development in this cohort.
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U2 - 10.1016/j.ophtha.2007.03.074
DO - 10.1016/j.ophtha.2007.03.074
M3 - Article
C2 - 17613328
AN - SCOPUS:34347342867
SN - 0161-6420
VL - 114
SP - 1378
EP - 1383
JO - Ophthalmology
JF - Ophthalmology
IS - 7
ER -