Abstract
The incidence of secondary monoclonal gammopathy of undetermined significance is limited in patients with multiple myeloma post chimeric antigen receptor T-cell therapy. This is a case of secondary monoclonal gammopathy of undetermined significance with the appearance of distinct paraprotein peaks demonstrating isotype switching from IgA lambda to IgG lambda within 6 months post autologous chimeric antigen receptor T-cell therapy in a 66 year old multiple myeloma patient. Secondary monoclonal gammopathy of undetermined significance with or without isotype switching and/or new paraprotein bands may be a rare but important example of a benign and transient phenomenon representing pseudo-disease progression and potentially associated with longer progression-free survival and better overall outcomes. Although such association remains speculative given paucity of literature and an absence of high-quality data.
Original language | English (US) |
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Article number | 100276 |
Journal | Current Problems in Cancer: Case Reports |
Volume | 13 |
DOIs | |
State | Published - Mar 2024 |
Keywords
- CAR T-cell therapy
- Case report
- Isotype switching
- Multiple myeloma
- Secondary monoclonal gammopathy of unknown significance
ASJC Scopus subject areas
- Oncology