Secretion of a chemotactic substance(s) by AGE-stimulated human monocytes

Michael Z. Gilcrease; Richard L. Hoover

doi:10.1016/0168-8227(92)90129-F

Secretion of a chemotactic substance(s) by AGE-stimulated human monocytes

Michael Z. Gilcrease, Richard L. Hoover

Pathology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Receptors for products of non-enzymatic glycosylation have been identified previously on activated human monocytes. In this study we have found that medium conditioned by activated human monocytes following stimulation with AGE-BSA elicited an almost 3-fold greater chemotactic response from other activated monocytes than conditioned medium obtained following stimulation with control BSA (44 ± 13 and 16 ± 4.6, respectively; n = 9, P < 0.05). The response elicited from AGE-BSA alone was not statistically significant. It appears that stimulation of the cells via the AGE-receptor results in the secretion of increased levels of a chemotactic substance(s) for monocytes/macrophages. This mechanism may help to explain the pathogenesis of atherosclerosis in diabetes, as monocyte accumulation within the vessel wall is an important step in fatty streak development.

Original language	English (US)
Pages (from-to)	7-11
Number of pages	5
Journal	Diabetes Research and Clinical Practice
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0168-8227(92)90129-F
State	Published - Apr 1992

Keywords

AGE-receptor
Chemotaxis
Diabetes
Monocyte
Non-enzymatic glycosylation

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/0168-8227(92)90129-F

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title = "Secretion of a chemotactic substance(s) by AGE-stimulated human monocytes",

abstract = "Receptors for products of non-enzymatic glycosylation have been identified previously on activated human monocytes. In this study we have found that medium conditioned by activated human monocytes following stimulation with AGE-BSA elicited an almost 3-fold greater chemotactic response from other activated monocytes than conditioned medium obtained following stimulation with control BSA (44 ± 13 and 16 ± 4.6, respectively; n = 9, P < 0.05). The response elicited from AGE-BSA alone was not statistically significant. It appears that stimulation of the cells via the AGE-receptor results in the secretion of increased levels of a chemotactic substance(s) for monocytes/macrophages. This mechanism may help to explain the pathogenesis of atherosclerosis in diabetes, as monocyte accumulation within the vessel wall is an important step in fatty streak development.",

keywords = "AGE-receptor, Chemotaxis, Diabetes, Monocyte, Non-enzymatic glycosylation",

author = "Gilcrease, {Michael Z.} and Hoover, {Richard L.}",

note = "Funding Information: We wish to thank Rhoda Jones for her excellent technicala ssistanceT. his work was supportedb y NIH grant HL-36526 to RLH.",

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T1 - Secretion of a chemotactic substance(s) by AGE-stimulated human monocytes

AU - Gilcrease, Michael Z.

AU - Hoover, Richard L.

N1 - Funding Information: We wish to thank Rhoda Jones for her excellent technicala ssistanceT. his work was supportedb y NIH grant HL-36526 to RLH.

PY - 1992/4

Y1 - 1992/4

N2 - Receptors for products of non-enzymatic glycosylation have been identified previously on activated human monocytes. In this study we have found that medium conditioned by activated human monocytes following stimulation with AGE-BSA elicited an almost 3-fold greater chemotactic response from other activated monocytes than conditioned medium obtained following stimulation with control BSA (44 ± 13 and 16 ± 4.6, respectively; n = 9, P < 0.05). The response elicited from AGE-BSA alone was not statistically significant. It appears that stimulation of the cells via the AGE-receptor results in the secretion of increased levels of a chemotactic substance(s) for monocytes/macrophages. This mechanism may help to explain the pathogenesis of atherosclerosis in diabetes, as monocyte accumulation within the vessel wall is an important step in fatty streak development.

AB - Receptors for products of non-enzymatic glycosylation have been identified previously on activated human monocytes. In this study we have found that medium conditioned by activated human monocytes following stimulation with AGE-BSA elicited an almost 3-fold greater chemotactic response from other activated monocytes than conditioned medium obtained following stimulation with control BSA (44 ± 13 and 16 ± 4.6, respectively; n = 9, P < 0.05). The response elicited from AGE-BSA alone was not statistically significant. It appears that stimulation of the cells via the AGE-receptor results in the secretion of increased levels of a chemotactic substance(s) for monocytes/macrophages. This mechanism may help to explain the pathogenesis of atherosclerosis in diabetes, as monocyte accumulation within the vessel wall is an important step in fatty streak development.

KW - AGE-receptor

KW - Chemotaxis

KW - Diabetes

KW - Monocyte

KW - Non-enzymatic glycosylation

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Secretion of a chemotactic substance(s) by AGE-stimulated human monocytes

Abstract

Keywords

ASJC Scopus subject areas

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