TY - JOUR
T1 - Seed and soil revisited
T2 - Contribution of the organ microenvironment to cancer metastasis
AU - Fidler, I. J.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - The outcome of cancer metastasis depends on multiple interactions (cross-talk) between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The organ microenvironment can influence the biology of cancer growth, angiogenesis, and metastasis in several different ways. Therapy of metastasis, therefore, should be targeted not only against metastatic tumor cells, but also the homeostatic factors that are favorable to metastasis, growth, and survival of the metastatic cells.
AB - The outcome of cancer metastasis depends on multiple interactions (cross-talk) between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The organ microenvironment can influence the biology of cancer growth, angiogenesis, and metastasis in several different ways. Therapy of metastasis, therefore, should be targeted not only against metastatic tumor cells, but also the homeostatic factors that are favorable to metastasis, growth, and survival of the metastatic cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035005758&partnerID=8YFLogxK
U2 - 10.1016/s1055-3207(18)30064-4
DO - 10.1016/s1055-3207(18)30064-4
M3 - Review article
C2 - 11382586
AN - SCOPUS:0035005758
SN - 1055-3207
VL - 10
SP - 257
EP - 269
JO - Surgical oncology clinics of North America
JF - Surgical oncology clinics of North America
IS - 2
ER -