TY - JOUR
T1 - Seeing What's Out of Sight
T2 - Wireless Capsule Endoscopy's Unique Ability to Visualize and Accurately Assess the Severity of Gastrointestinal Graft-versus-Host-Disease
AU - Varadarajan, Prakash
AU - Dunford, Lauren M.
AU - Thomas, Julie A.
AU - Brown, Karen
AU - Paplham, Pamela
AU - Syta, Margaret
AU - Schiff, Michael
AU - Padmanabhan, Swamithan
AU - Battiwalla, Minoo
AU - Smiley, Shannon
AU - Hahn, Theresa
AU - McCarthy, Philip L.
PY - 2009/5
Y1 - 2009/5
N2 - Early recognition of gastrointestinal graft-versus-host disease (GI GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) is vital to initiation of therapy. However, the most common location, the small bowel (SB), is difficult to access with upper and lower endoscopy (UGE/LGE). Wireless capsule endoscopy (WCE) is a noninvasive technology allowing complete SB evaluation. The capsule location can also be tracked to identify motility derangements. From August 2006 to July 2007, 11 alloHSCT patients with GI symptoms underwent WCE, and visual grading was performed. UGE and LGE with biopsies were done when clinically indicated. All patients had evidence of probable acute GVHD (aGVHD) on WCE. WCE revealed lesions of greater severity than those seen by UGE or LGE in most patients. WCE demonstrated that 45% of patients had delayed gastric transit time. WCE is an excellent, noninvasive method for assessing GI GVHD, with the ability to more accurately assess the severity of GVHD, evaluate clinical symptoms, and follow response to treatment.
AB - Early recognition of gastrointestinal graft-versus-host disease (GI GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) is vital to initiation of therapy. However, the most common location, the small bowel (SB), is difficult to access with upper and lower endoscopy (UGE/LGE). Wireless capsule endoscopy (WCE) is a noninvasive technology allowing complete SB evaluation. The capsule location can also be tracked to identify motility derangements. From August 2006 to July 2007, 11 alloHSCT patients with GI symptoms underwent WCE, and visual grading was performed. UGE and LGE with biopsies were done when clinically indicated. All patients had evidence of probable acute GVHD (aGVHD) on WCE. WCE revealed lesions of greater severity than those seen by UGE or LGE in most patients. WCE demonstrated that 45% of patients had delayed gastric transit time. WCE is an excellent, noninvasive method for assessing GI GVHD, with the ability to more accurately assess the severity of GVHD, evaluate clinical symptoms, and follow response to treatment.
KW - GVHD
KW - Gastrointestinal
KW - Graft-versus-host disease
KW - WCE
KW - Wireless capsule endoscopy
UR - http://www.scopus.com/inward/record.url?scp=63749129504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63749129504&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2009.02.002
DO - 10.1016/j.bbmt.2009.02.002
M3 - Article
C2 - 19361758
AN - SCOPUS:63749129504
SN - 1083-8791
VL - 15
SP - 643
EP - 648
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 5
ER -